Pathogen induced subversion of NAD(+) metabolism mediating host cell death: a target for development of chemotherapeutics

Hijacking of host metabolic status by a pathogen for its regulated dissemination from the host is prerequisite for the propagation of infection. M. tuberculosis secretes an NAD(+)-glycohydrolase, TNT, to induce host necroptosis by hydrolyzing Nicotinamide adenine dinucleotide (NAD(+)). Herein, we ex...

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Detalles Bibliográficos
Autores principales: Chaurasiya, Ayushi, Garg, Swati, Khanna, Ashish, Narayana, Chintam, Dwivedi, Ved Prakash, Joshi, Nishant, e Anam, Zill, Singh, Niharika, Singhal, Jhalak, Kaushik, Shikha, Kaur Kahlon, Amandeep, Srivastava, Pallavi, Marothia, Manisha, Kumar, Mukesh, Kumar, Santosh, Kumari, Geeta, Munjal, Akshay, Gupta, Sonal, Singh, Preeti, Pati, Soumya, Das, Gobardhan, Sagar, Ram, Ranganathan, Anand, Singh, Shailja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806871/
https://www.ncbi.nlm.nih.gov/pubmed/33441562
http://dx.doi.org/10.1038/s41420-020-00366-z

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