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Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA). For this reason, ADAMTS-5 is a pharmaceutical target for the treatment of OA. ADAMTS-5...

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Detalles Bibliográficos
Autores principales:	Santamaria, Salvatore, Cuffaro, Doretta, Nuti, Elisa, Ciccone, Lidia, Tuccinardi, Tiziano, Liva, Francesca, D’Andrea, Felicia, de Groot, Rens, Rossello, Armando, Ahnström, Josefin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806935/ https://www.ncbi.nlm.nih.gov/pubmed/33441904 http://dx.doi.org/10.1038/s41598-020-80294-1

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