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Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels

We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recen...

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Autores principales: Debortoli, Guilherme, de Araujo, Gilderlanio Santana, Fortes-Lima, Cesar, Parra, Esteban J., Suarez-Kurtz, Guilherme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806998/
https://www.ncbi.nlm.nih.gov/pubmed/33441860
http://dx.doi.org/10.1038/s41598-020-80389-9
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author Debortoli, Guilherme
de Araujo, Gilderlanio Santana
Fortes-Lima, Cesar
Parra, Esteban J.
Suarez-Kurtz, Guilherme
author_facet Debortoli, Guilherme
de Araujo, Gilderlanio Santana
Fortes-Lima, Cesar
Parra, Esteban J.
Suarez-Kurtz, Guilherme
author_sort Debortoli, Guilherme
collection PubMed
description We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populations throughout the Americas, with the Preemptive PGx and DMET panels performing better than the VIP panel. We show that these panels provide reliable information about biogeographic ancestry and can be used to guide the implementation of PGx clinical decision-support (CDS) tools. We also report that using these panels it is possible to control for the effects of population stratification in association studies in recently admixed populations, as exemplified with a warfarin dosing GWA study in a sample from Brazil.
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spelling pubmed-78069982021-01-14 Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels Debortoli, Guilherme de Araujo, Gilderlanio Santana Fortes-Lima, Cesar Parra, Esteban J. Suarez-Kurtz, Guilherme Sci Rep Article We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populations throughout the Americas, with the Preemptive PGx and DMET panels performing better than the VIP panel. We show that these panels provide reliable information about biogeographic ancestry and can be used to guide the implementation of PGx clinical decision-support (CDS) tools. We also report that using these panels it is possible to control for the effects of population stratification in association studies in recently admixed populations, as exemplified with a warfarin dosing GWA study in a sample from Brazil. Nature Publishing Group UK 2021-01-13 /pmc/articles/PMC7806998/ /pubmed/33441860 http://dx.doi.org/10.1038/s41598-020-80389-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Debortoli, Guilherme
de Araujo, Gilderlanio Santana
Fortes-Lima, Cesar
Parra, Esteban J.
Suarez-Kurtz, Guilherme
Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
title Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
title_full Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
title_fullStr Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
title_full_unstemmed Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
title_short Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
title_sort identification of ancestry proportions in admixed groups across the americas using clinical pharmacogenomic snp panels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806998/
https://www.ncbi.nlm.nih.gov/pubmed/33441860
http://dx.doi.org/10.1038/s41598-020-80389-9
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