Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle

Phosphorylated H2A.X is a critical chromatin marker of DNA damage repair (DDR) in higher eukaryotes. However, H2A.X gene expression remains relatively uncharacterised. Replication-dependent (RD) histone genes generate poly(A)- mRNA encoding new histones to package DNA during replication. In contrast...

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Detalles Bibliográficos
Autores principales: Griesbach, Esther, Schlackow, Margarita, Marzluff, William F., Proudfoot, Nick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807067/
https://www.ncbi.nlm.nih.gov/pubmed/33441544
http://dx.doi.org/10.1038/s41467-020-20520-6

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