Usefulness of Rapid Desensitization Therapy for Severe Rash Caused by Molecularly Targeted Drugs Used in the Treatment of Non-small-cell Lung Cancer

Molecular-targeted drugs (MTDs), such as epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and anaplastic lymphoma kinase inhibitors, are used to treat non-small-cell lung cancer (NSCLC). The incidence of rash caused by EGFR-TKIs and discontinuation of MTDs because of rash are...

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Autores principales: Nagase, Maki, Ohshima, Nobuharu, Kawashima, Masahiro, Ohgiya, Masahiro, Ikeda, Miki, Morio, Yoshiteru, Tamura, Atsuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807110/
https://www.ncbi.nlm.nih.gov/pubmed/32788540
http://dx.doi.org/10.2169/internalmedicine.5048-20
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author Nagase, Maki
Ohshima, Nobuharu
Kawashima, Masahiro
Ohgiya, Masahiro
Ikeda, Miki
Morio, Yoshiteru
Tamura, Atsuhisa
author_facet Nagase, Maki
Ohshima, Nobuharu
Kawashima, Masahiro
Ohgiya, Masahiro
Ikeda, Miki
Morio, Yoshiteru
Tamura, Atsuhisa
author_sort Nagase, Maki
collection PubMed
description Molecular-targeted drugs (MTDs), such as epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and anaplastic lymphoma kinase inhibitors, are used to treat non-small-cell lung cancer (NSCLC). The incidence of rash caused by EGFR-TKIs and discontinuation of MTDs because of rash are issues. Rapid desensitization therapy (RDT) was performed in five patients who developed severe rash after introduction of MTDs and was successful in four, all of whom showed no rash relapse. RDT may thus be useful for treating rash in patients receiving MTDs for NSCLC.
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spelling pubmed-78071102021-01-27 Usefulness of Rapid Desensitization Therapy for Severe Rash Caused by Molecularly Targeted Drugs Used in the Treatment of Non-small-cell Lung Cancer Nagase, Maki Ohshima, Nobuharu Kawashima, Masahiro Ohgiya, Masahiro Ikeda, Miki Morio, Yoshiteru Tamura, Atsuhisa Intern Med Case Report Molecular-targeted drugs (MTDs), such as epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and anaplastic lymphoma kinase inhibitors, are used to treat non-small-cell lung cancer (NSCLC). The incidence of rash caused by EGFR-TKIs and discontinuation of MTDs because of rash are issues. Rapid desensitization therapy (RDT) was performed in five patients who developed severe rash after introduction of MTDs and was successful in four, all of whom showed no rash relapse. RDT may thus be useful for treating rash in patients receiving MTDs for NSCLC. The Japanese Society of Internal Medicine 2020-08-12 2020-12-15 /pmc/articles/PMC7807110/ /pubmed/32788540 http://dx.doi.org/10.2169/internalmedicine.5048-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nagase, Maki
Ohshima, Nobuharu
Kawashima, Masahiro
Ohgiya, Masahiro
Ikeda, Miki
Morio, Yoshiteru
Tamura, Atsuhisa
Usefulness of Rapid Desensitization Therapy for Severe Rash Caused by Molecularly Targeted Drugs Used in the Treatment of Non-small-cell Lung Cancer
title Usefulness of Rapid Desensitization Therapy for Severe Rash Caused by Molecularly Targeted Drugs Used in the Treatment of Non-small-cell Lung Cancer
title_full Usefulness of Rapid Desensitization Therapy for Severe Rash Caused by Molecularly Targeted Drugs Used in the Treatment of Non-small-cell Lung Cancer
title_fullStr Usefulness of Rapid Desensitization Therapy for Severe Rash Caused by Molecularly Targeted Drugs Used in the Treatment of Non-small-cell Lung Cancer
title_full_unstemmed Usefulness of Rapid Desensitization Therapy for Severe Rash Caused by Molecularly Targeted Drugs Used in the Treatment of Non-small-cell Lung Cancer
title_short Usefulness of Rapid Desensitization Therapy for Severe Rash Caused by Molecularly Targeted Drugs Used in the Treatment of Non-small-cell Lung Cancer
title_sort usefulness of rapid desensitization therapy for severe rash caused by molecularly targeted drugs used in the treatment of non-small-cell lung cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807110/
https://www.ncbi.nlm.nih.gov/pubmed/32788540
http://dx.doi.org/10.2169/internalmedicine.5048-20
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