Disseminated Mycobacterium avium Infection Complicated with Chylous Ascites in a Patient with Neutralizing Autoantibodies to Interferon-γ

A 68-year-old man visited our hospital due to anorexia, weight loss and a fever. We diagnosed the patient with disseminated Mycobacterium avium complex (MAC) and confirmed the presence of interferon (IFN)-γ neutralizing autoantibodies (IFN-γAb). His lesions improved following antibiotic therapy, but...

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Autores principales: Yamaba, Yusuke, Takakuwa, Osamu, Wang, Ziren, Saito, Manami, Kawae, Daisuke, Yoshihara, Misuzu, Kunii, Eiji, Ito, Yutaka, Akita, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807119/
https://www.ncbi.nlm.nih.gov/pubmed/32788530
http://dx.doi.org/10.2169/internalmedicine.3987-19
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author Yamaba, Yusuke
Takakuwa, Osamu
Wang, Ziren
Saito, Manami
Kawae, Daisuke
Yoshihara, Misuzu
Kunii, Eiji
Ito, Yutaka
Akita, Kenji
author_facet Yamaba, Yusuke
Takakuwa, Osamu
Wang, Ziren
Saito, Manami
Kawae, Daisuke
Yoshihara, Misuzu
Kunii, Eiji
Ito, Yutaka
Akita, Kenji
author_sort Yamaba, Yusuke
collection PubMed
description A 68-year-old man visited our hospital due to anorexia, weight loss and a fever. We diagnosed the patient with disseminated Mycobacterium avium complex (MAC) and confirmed the presence of interferon (IFN)-γ neutralizing autoantibodies (IFN-γAb). His lesions improved following antibiotic therapy, but chylous ascites (CA) developed seven months after treatment. CA was able to be controlled by subcutaneous octreotide and diet therapy. IFN-γAb is recognized as having a critical role in the pathogenesis of disseminated MAC disease, but its clinical features are not fully understood. CA may be a complication that develops during the treatment of disseminated MAC infection.
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spelling pubmed-78071192021-01-27 Disseminated Mycobacterium avium Infection Complicated with Chylous Ascites in a Patient with Neutralizing Autoantibodies to Interferon-γ Yamaba, Yusuke Takakuwa, Osamu Wang, Ziren Saito, Manami Kawae, Daisuke Yoshihara, Misuzu Kunii, Eiji Ito, Yutaka Akita, Kenji Intern Med Case Report A 68-year-old man visited our hospital due to anorexia, weight loss and a fever. We diagnosed the patient with disseminated Mycobacterium avium complex (MAC) and confirmed the presence of interferon (IFN)-γ neutralizing autoantibodies (IFN-γAb). His lesions improved following antibiotic therapy, but chylous ascites (CA) developed seven months after treatment. CA was able to be controlled by subcutaneous octreotide and diet therapy. IFN-γAb is recognized as having a critical role in the pathogenesis of disseminated MAC disease, but its clinical features are not fully understood. CA may be a complication that develops during the treatment of disseminated MAC infection. The Japanese Society of Internal Medicine 2020-08-12 2020-12-15 /pmc/articles/PMC7807119/ /pubmed/32788530 http://dx.doi.org/10.2169/internalmedicine.3987-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yamaba, Yusuke
Takakuwa, Osamu
Wang, Ziren
Saito, Manami
Kawae, Daisuke
Yoshihara, Misuzu
Kunii, Eiji
Ito, Yutaka
Akita, Kenji
Disseminated Mycobacterium avium Infection Complicated with Chylous Ascites in a Patient with Neutralizing Autoantibodies to Interferon-γ
title Disseminated Mycobacterium avium Infection Complicated with Chylous Ascites in a Patient with Neutralizing Autoantibodies to Interferon-γ
title_full Disseminated Mycobacterium avium Infection Complicated with Chylous Ascites in a Patient with Neutralizing Autoantibodies to Interferon-γ
title_fullStr Disseminated Mycobacterium avium Infection Complicated with Chylous Ascites in a Patient with Neutralizing Autoantibodies to Interferon-γ
title_full_unstemmed Disseminated Mycobacterium avium Infection Complicated with Chylous Ascites in a Patient with Neutralizing Autoantibodies to Interferon-γ
title_short Disseminated Mycobacterium avium Infection Complicated with Chylous Ascites in a Patient with Neutralizing Autoantibodies to Interferon-γ
title_sort disseminated mycobacterium avium infection complicated with chylous ascites in a patient with neutralizing autoantibodies to interferon-γ
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807119/
https://www.ncbi.nlm.nih.gov/pubmed/32788530
http://dx.doi.org/10.2169/internalmedicine.3987-19
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