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Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes
OBJECTIVE: Aging and weight gain lead to a decline in brown and beige adipocyte functionality that exacerbates obesity and insulin resistance. We sought to determine whether sphingolipids, such as ceramides, a class of lipid metabolites that accumulate in aging and overnutrition, are sufficient or n...
Autores principales: | Chaurasia, Bhagirath, Ying, Li, Talbot, Chad Lamar, Maschek, John Alan, Cox, James, Schuchman, Edward H., Hirabayashi, Yoshio, Holland, William L., Summers, Scott A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807150/ https://www.ncbi.nlm.nih.gov/pubmed/33352310 http://dx.doi.org/10.1016/j.molmet.2020.101145 |
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