Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays

SARS-CoV-2, the virus that causes COVID-19 consists of several enzymes with essential functions within its proteome. Here, we focused on repurposing approved and investigational drugs/compounds. We targeted seven proteins with enzymatic activities known to be essential at different stages of the vir...

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Detalles Bibliográficos
Autores principales: Gupta, Yash, Maciorowski, Dawid, Zak, Samantha E., Jones, Krysten A., Kathayat, Rahul S., Azizi, Saara-Anne, Mathur, Raman, Pearce, Catherine M, Ilc, David J., Husein, Hamza, Herbert, Andrew S., Bharti, Ajay, Rathi, Brijesh, Durvasula, Ravi, Becker, Daniel P., Dickinson, Bryan C., Dye, John M., Kempaiah, Prakasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807167/
https://www.ncbi.nlm.nih.gov/pubmed/33453392
http://dx.doi.org/10.1016/j.ymeth.2021.01.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807167/
https://www.ncbi.nlm.nih.gov/pubmed/33453392
http://dx.doi.org/10.1016/j.ymeth.2021.01.003

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