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Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury

Background: Cathelicidins are ancient and well-conserved antimicrobial peptides (AMPs) with intriguing immunomodulatory properties in both infectious and non-infectious inflammatory diseases. In addition to direct antimicrobial activity, cathelicidins also participate in several signaling pathways i...

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Autores principales: da Silva, Beatriz Helena Cermaria Soares, Ariga, Suely Kubo, Barbeiro, Hermes Vieira, Volpini, Rildo Aparecido, Barbeiro, Denise Frediani, Seguro, Antonio Carlos, Pinheiro da Silva, Fabiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807180/
https://www.ncbi.nlm.nih.gov/pubmed/33456345
http://dx.doi.org/10.7150/ijms.52397
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author da Silva, Beatriz Helena Cermaria Soares
Ariga, Suely Kubo
Barbeiro, Hermes Vieira
Volpini, Rildo Aparecido
Barbeiro, Denise Frediani
Seguro, Antonio Carlos
Pinheiro da Silva, Fabiano
author_facet da Silva, Beatriz Helena Cermaria Soares
Ariga, Suely Kubo
Barbeiro, Hermes Vieira
Volpini, Rildo Aparecido
Barbeiro, Denise Frediani
Seguro, Antonio Carlos
Pinheiro da Silva, Fabiano
author_sort da Silva, Beatriz Helena Cermaria Soares
collection PubMed
description Background: Cathelicidins are ancient and well-conserved antimicrobial peptides (AMPs) with intriguing immunomodulatory properties in both infectious and non-infectious inflammatory diseases. In addition to direct antimicrobial activity, cathelicidins also participate in several signaling pathways inducing both pro-inflammatory and anti-inflammatory effects. Acute kidney injury (AKI) is common in critically ill patients and is associated with high mortality and morbidity. Rhabdomyolysis is a major trigger of AKI. Objectives: Here, we investigated the role of cathelicidins in non-infectious Acute kidney Injury (AKI). Method: Using an experimental model of rhabdomyolysis, we induced AKI in wild-type and cathelicidin-related AMP knockout (CRAMP(-/-)) mice. Results: We previously demonstrated that CRAMP(-/-) mice, as opposed wild-type mice, are protected from AKI during sepsis induced by cecal ligation and puncture. Conversely, in the current study, we show that CRAMP(-/-) mice are more susceptible to the rhabdomyolysis model of AKI. A more in-depth investigation of wild-type and CRAMP(-/-) mice revealed important differences in the levels of several inflammatory mediators. Conclusion: Cathelicidins can induce a varied and even opposing repertoire of immune-inflammatory responses depending on the subjacent disease and the cellular context.
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spelling pubmed-78071802021-01-15 Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury da Silva, Beatriz Helena Cermaria Soares Ariga, Suely Kubo Barbeiro, Hermes Vieira Volpini, Rildo Aparecido Barbeiro, Denise Frediani Seguro, Antonio Carlos Pinheiro da Silva, Fabiano Int J Med Sci Research Paper Background: Cathelicidins are ancient and well-conserved antimicrobial peptides (AMPs) with intriguing immunomodulatory properties in both infectious and non-infectious inflammatory diseases. In addition to direct antimicrobial activity, cathelicidins also participate in several signaling pathways inducing both pro-inflammatory and anti-inflammatory effects. Acute kidney injury (AKI) is common in critically ill patients and is associated with high mortality and morbidity. Rhabdomyolysis is a major trigger of AKI. Objectives: Here, we investigated the role of cathelicidins in non-infectious Acute kidney Injury (AKI). Method: Using an experimental model of rhabdomyolysis, we induced AKI in wild-type and cathelicidin-related AMP knockout (CRAMP(-/-)) mice. Results: We previously demonstrated that CRAMP(-/-) mice, as opposed wild-type mice, are protected from AKI during sepsis induced by cecal ligation and puncture. Conversely, in the current study, we show that CRAMP(-/-) mice are more susceptible to the rhabdomyolysis model of AKI. A more in-depth investigation of wild-type and CRAMP(-/-) mice revealed important differences in the levels of several inflammatory mediators. Conclusion: Cathelicidins can induce a varied and even opposing repertoire of immune-inflammatory responses depending on the subjacent disease and the cellular context. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7807180/ /pubmed/33456345 http://dx.doi.org/10.7150/ijms.52397 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
da Silva, Beatriz Helena Cermaria Soares
Ariga, Suely Kubo
Barbeiro, Hermes Vieira
Volpini, Rildo Aparecido
Barbeiro, Denise Frediani
Seguro, Antonio Carlos
Pinheiro da Silva, Fabiano
Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury
title Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury
title_full Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury
title_fullStr Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury
title_full_unstemmed Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury
title_short Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury
title_sort cathelicidin protects mice from rhabdomyolysis-induced acute kidney injury
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807180/
https://www.ncbi.nlm.nih.gov/pubmed/33456345
http://dx.doi.org/10.7150/ijms.52397
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