Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial

A fungal metabolite, diatretol, has shown to be a promising antimalarial agent. Diatretol displayed potent in vitro antiparasitic activity against the Plasmodium falciparum K1 strain, with an IC(50) value of 378 ng ml(−1), as well as in vivo efficacy in a Plasmodium berghei-infected mice model, with...

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Autores principales: Ishiyama, Aki, Hokari, Rei, Nonaka, Kenichi, Chiba, Takuya, Miura, Hiromi, Otoguro, Kazuhiko, Iwatsuki, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807217/
https://www.ncbi.nlm.nih.gov/pubmed/33446930
http://dx.doi.org/10.1038/s41429-020-00390-2
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author Ishiyama, Aki
Hokari, Rei
Nonaka, Kenichi
Chiba, Takuya
Miura, Hiromi
Otoguro, Kazuhiko
Iwatsuki, Masato
author_facet Ishiyama, Aki
Hokari, Rei
Nonaka, Kenichi
Chiba, Takuya
Miura, Hiromi
Otoguro, Kazuhiko
Iwatsuki, Masato
author_sort Ishiyama, Aki
collection PubMed
description A fungal metabolite, diatretol, has shown to be a promising antimalarial agent. Diatretol displayed potent in vitro antiparasitic activity against the Plasmodium falciparum K1 strain, with an IC(50) value of 378 ng ml(−1), as well as in vivo efficacy in a Plasmodium berghei-infected mice model, with ca. 50% inhibition at 30 mg/kg (p.o.).
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spelling pubmed-78072172021-01-14 Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial Ishiyama, Aki Hokari, Rei Nonaka, Kenichi Chiba, Takuya Miura, Hiromi Otoguro, Kazuhiko Iwatsuki, Masato J Antibiot (Tokyo) Brief Communication A fungal metabolite, diatretol, has shown to be a promising antimalarial agent. Diatretol displayed potent in vitro antiparasitic activity against the Plasmodium falciparum K1 strain, with an IC(50) value of 378 ng ml(−1), as well as in vivo efficacy in a Plasmodium berghei-infected mice model, with ca. 50% inhibition at 30 mg/kg (p.o.). Nature Publishing Group UK 2021-01-14 2021 /pmc/articles/PMC7807217/ /pubmed/33446930 http://dx.doi.org/10.1038/s41429-020-00390-2 Text en © The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Communication
Ishiyama, Aki
Hokari, Rei
Nonaka, Kenichi
Chiba, Takuya
Miura, Hiromi
Otoguro, Kazuhiko
Iwatsuki, Masato
Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial
title Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial
title_full Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial
title_fullStr Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial
title_full_unstemmed Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial
title_short Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial
title_sort diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807217/
https://www.ncbi.nlm.nih.gov/pubmed/33446930
http://dx.doi.org/10.1038/s41429-020-00390-2
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