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Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial
A fungal metabolite, diatretol, has shown to be a promising antimalarial agent. Diatretol displayed potent in vitro antiparasitic activity against the Plasmodium falciparum K1 strain, with an IC(50) value of 378 ng ml(−1), as well as in vivo efficacy in a Plasmodium berghei-infected mice model, with...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807217/ https://www.ncbi.nlm.nih.gov/pubmed/33446930 http://dx.doi.org/10.1038/s41429-020-00390-2 |