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Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience
BACKGROUND: Type 1 diabetes (T1D) contributes to altered lipid profiles and increases the risk of cardiovascular disease (CVD). Youth with T1D may have additional CVD risk factors within the first decade of diagnosis. AIM: To examine risk factors for dyslipidemia in young subjects with T1D. METHODS:...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807252/ https://www.ncbi.nlm.nih.gov/pubmed/33520108 http://dx.doi.org/10.4239/wjd.v12.i1.56 |
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author | Krepel Volsky, Sari Shalitin, Shlomit Fridman, Elena Yackobovitch-Gavan, Michal Lazar, Liora Bello, Rachel Oron, Tal Tenenbaum, Ariel de Vries, Liat Lebenthal, Yael |
author_facet | Krepel Volsky, Sari Shalitin, Shlomit Fridman, Elena Yackobovitch-Gavan, Michal Lazar, Liora Bello, Rachel Oron, Tal Tenenbaum, Ariel de Vries, Liat Lebenthal, Yael |
author_sort | Krepel Volsky, Sari |
collection | PubMed |
description | BACKGROUND: Type 1 diabetes (T1D) contributes to altered lipid profiles and increases the risk of cardiovascular disease (CVD). Youth with T1D may have additional CVD risk factors within the first decade of diagnosis. AIM: To examine risk factors for dyslipidemia in young subjects with T1D. METHODS: Longitudinal and cross-sectional retrospective study of 170 young subjects with T1D (86 males; baseline mean age 12.2 ± 5.6 years and hemoglobin A1c 8.4% ± 1.4%) were followed in a single tertiary diabetes center for a median duration of 15 years. Predictors for outcomes of lipid profiles at last visit (total cholesterol [TC], triglycerides [TGs], low-density lipoprotein-cholesterol [LDL-c], and high-density lipoprotein-cholesterol [HDL-c]) were analyzed by stepwise linear regression models. RESULTS: At baseline, 79.5% of the patients had at least one additional CVD risk factor (borderline dyslipidemia/dyslipidemia [37.5%], pre-hypertension/hypertension [27.6%], and overweight/obesity [16.5%]) and 41.6% had multiple (≥ 2) CVD risk factors. A positive family history of at least one CVD risk factor in a first-degree relative was reported in 54.1% of the cohort. Predictors of elevated TC: family history of CVD (β[SE] = 23.1[8.3], P = 0.006); of elevated LDL-c: baseline diastolic blood pressure (DBP) (β[SE] = 11.4[4.7], P = 0.003) and family history of CVD (β[SE] = 20.7[6.8], P = 0.017); of elevated TGs: baseline DBP (β[SE] = 23.8[9.1], P = 0.010) and family history of CVD (β[SE] = 31.0[13.1], P = 0.020); and of low HDL-c levels: baseline DBP (β[SE] = 4.8[2.1], P = 0.022]). CONCLUSION: Our findings suggest that elevated lipid profiles are associated with DBP and a positive family history of CVD. It is of utmost importance to prevent and control modifiable risk factors such as these, as early as childhood, given that inadequate glycemic control and elevation in blood pressure intensify the risk of dyslipidemia. |
format | Online Article Text |
id | pubmed-7807252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-78072522021-01-28 Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience Krepel Volsky, Sari Shalitin, Shlomit Fridman, Elena Yackobovitch-Gavan, Michal Lazar, Liora Bello, Rachel Oron, Tal Tenenbaum, Ariel de Vries, Liat Lebenthal, Yael World J Diabetes Retrospective Study BACKGROUND: Type 1 diabetes (T1D) contributes to altered lipid profiles and increases the risk of cardiovascular disease (CVD). Youth with T1D may have additional CVD risk factors within the first decade of diagnosis. AIM: To examine risk factors for dyslipidemia in young subjects with T1D. METHODS: Longitudinal and cross-sectional retrospective study of 170 young subjects with T1D (86 males; baseline mean age 12.2 ± 5.6 years and hemoglobin A1c 8.4% ± 1.4%) were followed in a single tertiary diabetes center for a median duration of 15 years. Predictors for outcomes of lipid profiles at last visit (total cholesterol [TC], triglycerides [TGs], low-density lipoprotein-cholesterol [LDL-c], and high-density lipoprotein-cholesterol [HDL-c]) were analyzed by stepwise linear regression models. RESULTS: At baseline, 79.5% of the patients had at least one additional CVD risk factor (borderline dyslipidemia/dyslipidemia [37.5%], pre-hypertension/hypertension [27.6%], and overweight/obesity [16.5%]) and 41.6% had multiple (≥ 2) CVD risk factors. A positive family history of at least one CVD risk factor in a first-degree relative was reported in 54.1% of the cohort. Predictors of elevated TC: family history of CVD (β[SE] = 23.1[8.3], P = 0.006); of elevated LDL-c: baseline diastolic blood pressure (DBP) (β[SE] = 11.4[4.7], P = 0.003) and family history of CVD (β[SE] = 20.7[6.8], P = 0.017); of elevated TGs: baseline DBP (β[SE] = 23.8[9.1], P = 0.010) and family history of CVD (β[SE] = 31.0[13.1], P = 0.020); and of low HDL-c levels: baseline DBP (β[SE] = 4.8[2.1], P = 0.022]). CONCLUSION: Our findings suggest that elevated lipid profiles are associated with DBP and a positive family history of CVD. It is of utmost importance to prevent and control modifiable risk factors such as these, as early as childhood, given that inadequate glycemic control and elevation in blood pressure intensify the risk of dyslipidemia. Baishideng Publishing Group Inc 2021-01-15 2021-01-15 /pmc/articles/PMC7807252/ /pubmed/33520108 http://dx.doi.org/10.4239/wjd.v12.i1.56 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Retrospective Study Krepel Volsky, Sari Shalitin, Shlomit Fridman, Elena Yackobovitch-Gavan, Michal Lazar, Liora Bello, Rachel Oron, Tal Tenenbaum, Ariel de Vries, Liat Lebenthal, Yael Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience |
title | Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience |
title_full | Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience |
title_fullStr | Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience |
title_full_unstemmed | Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience |
title_short | Dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: A single-center experience |
title_sort | dyslipidemia and cardiovascular disease risk factors in patients with type 1 diabetes: a single-center experience |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807252/ https://www.ncbi.nlm.nih.gov/pubmed/33520108 http://dx.doi.org/10.4239/wjd.v12.i1.56 |
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