A Novel Next-Generation Sequencing Approach to Detecting Microsatellite Instability and Pan-Tumor Characterization of 1000 Microsatellite Instability–High Cases in 67,000 Patient Samples

Microsatellite instability (MSI) is an important biomarker for predicting response to immune checkpoint inhibitor therapy, as emphasized by the recent checkpoint inhibitor approval for MSI-high (MSI-H) solid tumors. Herein, we describe and validate a novel method for determining MSI status from a ne...

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Detalles Bibliográficos
Autores principales: Trabucco, Sally E., Gowen, Kyle, Maund, Sophia L., Sanford, Eric, Fabrizio, David A., Hall, Michael J., Yakirevich, Evgeny, Gregg, Jeffrey P., Stephens, Phil J., Frampton, Garrett M., Hegde, Priti S., Miller, Vincent A., Ross, Jeffrey S., Hartmaier, Ryan J., Huang, Shih-Min A., Sun, James X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Investigative Pathology 2019
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807551/
https://www.ncbi.nlm.nih.gov/pubmed/31445211
http://dx.doi.org/10.1016/j.jmoldx.2019.06.011

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