Cargando…

A receptor-antibody hybrid hampering MET-driven metastatic spread

BACKGROUND: The receptor encoded by the MET oncogene and its ligand Hepatocyte Growth Factor (HGF) are at the core of the invasive-metastatic behavior. In a number of instances genetic alterations result in ligand-independent onset of malignancy (MET addiction). More frequently, ligand stimulation o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Modica, Chiara, Basilico, Cristina, Chiriaco, Cristina, Borrelli, Nicla, Comoglio, Paolo M., Vigna, Elisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807714/ https://www.ncbi.nlm.nih.gov/pubmed/33446252 http://dx.doi.org/10.1186/s13046-020-01822-5

Ejemplares similares

Molecular Engineering Strategies Tailoring the Apoptotic Response to a MET Therapeutic Antibody
por: Modica, Chiara, et al.
Publicado: (2020)

hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers
por: Martinelli, Ilaria, et al.
Publicado: (2022)

Correction: hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers
por: Martinelli, Ilaria, et al.
Publicado: (2022)

MET/HGF Co-Targeting in Pancreatic Cancer: A Tool to Provide Insight into the Tumor/Stroma Crosstalk
por: Modica, Chiara, et al.
Publicado: (2018)

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours
por: Martin, Valentina, et al.
Publicado: (2019)

Efficacy of CAR-T immunotherapy in MET overexpressing tumors not eligible for anti-MET targeted therapy
por: Chiriaco, Cristina, et al.
Publicado: (2022)

HGF/MET Axis Induces Tumor Secretion of Tenascin-C and Promotes Stromal Rewiring in Pancreatic Cancer
por: Modica, Chiara, et al.
Publicado: (2021)

Genetic Ablation of the MET Oncogene Defines a Crucial Role of the HGF/MET Axis in Cell-Autonomous Functions Driving Tumor Dissemination
por: Modica, Chiara, et al.
Publicado: (2023)

A High Affinity Hepatocyte Growth Factor-binding Site in the Immunoglobulin-like Region of Met
por: Basilico, Cristina, et al.
Publicado: (2008)

Engineering, Characterization, and Biological Evaluation of an Antibody Targeting the HGF Receptor
por: Desole, Claudia, et al.
Publicado: (2021)

ROR1 is a pseudokinase that is crucial for MET-driven tumorigenesis
por: Lazzari, Luca, et al.
Publicado: (2013)

MET Activation and Physical Dynamics of the Metastatic Process: The Paradigm of Cancers of Unknown Primary Origin
por: Stella, Giulia M., et al.
Publicado: (2017)

Monoclonal Antibodies against the MET/HGF Receptor and Its Ligand: Multitask Tools with Applications from Basic Research to Therapy
por: Prat, Maria, et al.
Publicado: (2014)

MET∆14 promotes a ligand-dependent, AKT-driven invasive growth
por: Cerqua, Marina, et al.
Publicado: (2022)

An Observatory for the MET Oncogene: A Guide for Targeted Therapies
por: Altintas, Dogus M., et al.
Publicado: (2023)

The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor
por: Altintas, Dogus Murat, et al.
Publicado: (2022)

Magic-Factor 1, a Partial Agonist of Met, Induces Muscle Hypertrophy by Protecting Myogenic Progenitors from Apoptosis
por: Cassano, Marco, et al.
Publicado: (2008)

MET Oncogene Controls Invasive Growth by Coupling with NMDA Receptor
por: Gallo, Simona, et al.
Publicado: (2022)

Correction: Magic-Factor 1, a Partial Agonist of Met, Induces Muscle Hypertrophy by Protecting Myogenic Progenitors from Apoptosis
por: Cassano, Marco, et al.
Publicado: (2019)

Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis
por: Pham, Hien Thi Thu, et al.
Publicado: (2023)

The Met oncogene and basal-like breast cancer: another culprit to watch out for?
por: Gastaldi, Stefania, et al.
Publicado: (2010)

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition
por: Corso, Simona, et al.
Publicado: (2010)

Crippled Children's Hampers
por: Treloar, W. P.
Publicado: (1906)

Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node
por: van Pul, Kim M., et al.
Publicado: (2019)

Reviving oncogenic addiction to MET bypassed by BRAF (G469A) mutation
por: Virzì, Anna Rita, et al.
Publicado: (2018)

Salinomycin treatment reduces metastatic tumor burden by hampering cancer cell migration
por: Kopp, Florian, et al.
Publicado: (2014)

Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy
por: Gallo, S, et al.
Publicado: (2014)

Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy
por: Godar, Marie, et al.
Publicado: (2016)

HGF and MET: From Brain Development to Neurological Disorders
por: Desole, Claudia, et al.
Publicado: (2021)

Aging hampers neutrophil extracellular traps (NETs) efficacy
por: Sabbatini, Maurizio, et al.
Publicado: (2022)

Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease
por: Turri, Marta, et al.
Publicado: (2023)

Anti-Differentiation Effect of Oncogenic Met Receptor in Terminally-Differentiated Myotubes
por: Sala, Valentina, et al.
Publicado: (2015)

Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD(+) and SIRT3
por: Masgras, Ionica, et al.
Publicado: (2022)

Payoff information hampers the evolution of cooperation
por: Huck, Steffen, et al.
Publicado: (2017)

Legitimate Dental Practice Hampered by Law
Publicado: (1898)

TERT promoter mutations and their correlation with BRAF and RAS mutations in a consecutive cohort of 145 thyroid cancer cases
por: Insilla, Andrea Cacciato, et al.
Publicado: (2018)

Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism
por: Gritti, Ilaria, et al.
Publicado: (2022)

C-met inhibition blocks bone metastasis development induced by renal cancer stem cells
por: D'Amico, Lucia, et al.
Publicado: (2016)

A Natural Hepatocyte Growth Factor/Scatter Factor Autocrine Loop in Myoblast Cells and the Effect of the Constitutive Met Kinase Activation on Myogenic Differentiation
por: Anastasi, Sergio, et al.
Publicado: (1997)

High Expression Hampers Horizontal Gene Transfer
por: Park, Chungoo, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_gfujoddijq7dtdcm9nelju7fj3