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Anticancer Drug Release System Based on Hollow Silica Nanocarriers Triggered by Tumor Cellular Microenvironments
[Image: see text] Targeted release of anticancer drugs to tumor sites has a pivotal role in clinical oncology. pH-responsive drug delivery systems, with an intelligent and targeted release of anticancer drugs in a controllable manner based on sensitivities to the weakly acidic environments of tumor...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807753/ https://www.ncbi.nlm.nih.gov/pubmed/33458507 http://dx.doi.org/10.1021/acsomega.0c05032 |
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author | Deng, Shaoxin Cui, Cheng-Xing Duan, Lingyao Hu, Linfeng Yang, Xiaoxun Wang, Ji-Chao Qu, Ling-Bo Zhang, Yuping |
author_facet | Deng, Shaoxin Cui, Cheng-Xing Duan, Lingyao Hu, Linfeng Yang, Xiaoxun Wang, Ji-Chao Qu, Ling-Bo Zhang, Yuping |
author_sort | Deng, Shaoxin |
collection | PubMed |
description | [Image: see text] Targeted release of anticancer drugs to tumor sites has a pivotal role in clinical oncology. pH-responsive drug delivery systems, with an intelligent and targeted release of anticancer drugs in a controllable manner based on sensitivities to the weakly acidic environments of tumor cellular microenvironments, are desirable. Herein, the design of such a pH-responsive drug delivery system is detailed using in situ amino-functionalized hollow mesoporous silica nanoparticles as carriers. The drug release behavior of the pH-responsive delivery system was evaluated under an in vitro simulation of tumor cellular microenvironments. The drug delivery system has efficient drug loadings and targeted release. Zorubicin hydrochloride releasing percentage is almost up to 100% at a buffer pH of 5.0. The drug release systems described demonstrating great potential in anticancer therapy. |
format | Online Article Text |
id | pubmed-7807753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-78077532021-01-15 Anticancer Drug Release System Based on Hollow Silica Nanocarriers Triggered by Tumor Cellular Microenvironments Deng, Shaoxin Cui, Cheng-Xing Duan, Lingyao Hu, Linfeng Yang, Xiaoxun Wang, Ji-Chao Qu, Ling-Bo Zhang, Yuping ACS Omega [Image: see text] Targeted release of anticancer drugs to tumor sites has a pivotal role in clinical oncology. pH-responsive drug delivery systems, with an intelligent and targeted release of anticancer drugs in a controllable manner based on sensitivities to the weakly acidic environments of tumor cellular microenvironments, are desirable. Herein, the design of such a pH-responsive drug delivery system is detailed using in situ amino-functionalized hollow mesoporous silica nanoparticles as carriers. The drug release behavior of the pH-responsive delivery system was evaluated under an in vitro simulation of tumor cellular microenvironments. The drug delivery system has efficient drug loadings and targeted release. Zorubicin hydrochloride releasing percentage is almost up to 100% at a buffer pH of 5.0. The drug release systems described demonstrating great potential in anticancer therapy. American Chemical Society 2020-12-29 /pmc/articles/PMC7807753/ /pubmed/33458507 http://dx.doi.org/10.1021/acsomega.0c05032 Text en © 2020 The Authors. Published by American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes. |
spellingShingle | Deng, Shaoxin Cui, Cheng-Xing Duan, Lingyao Hu, Linfeng Yang, Xiaoxun Wang, Ji-Chao Qu, Ling-Bo Zhang, Yuping Anticancer Drug Release System Based on Hollow Silica Nanocarriers Triggered by Tumor Cellular Microenvironments |
title | Anticancer Drug Release System Based on Hollow Silica
Nanocarriers Triggered by Tumor Cellular Microenvironments |
title_full | Anticancer Drug Release System Based on Hollow Silica
Nanocarriers Triggered by Tumor Cellular Microenvironments |
title_fullStr | Anticancer Drug Release System Based on Hollow Silica
Nanocarriers Triggered by Tumor Cellular Microenvironments |
title_full_unstemmed | Anticancer Drug Release System Based on Hollow Silica
Nanocarriers Triggered by Tumor Cellular Microenvironments |
title_short | Anticancer Drug Release System Based on Hollow Silica
Nanocarriers Triggered by Tumor Cellular Microenvironments |
title_sort | anticancer drug release system based on hollow silica
nanocarriers triggered by tumor cellular microenvironments |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807753/ https://www.ncbi.nlm.nih.gov/pubmed/33458507 http://dx.doi.org/10.1021/acsomega.0c05032 |
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