A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity

BACKGROUND: Aberrant activation of the Hedgehog pathway drives tumorigenesis of many cancers, including glioblastoma. However, the sensitization mechanism of the G protein-coupled-like receptor smoothened (SMO), a key component of Hedgehog signaling, remains largely unknown. RESULTS: In this study,...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xujia, Xiao, Songhua, Zhang, Maolei, Yang, Lixuan, Zhong, Jian, Li, Bo, Li, Fanying, Xia, Xin, Li, Xixi, Zhou, Huangkai, Liu, Dawei, Huang, Nunu, Yang, Xuesong, Xiao, Feizhe, Zhang, Nu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807754/
https://www.ncbi.nlm.nih.gov/pubmed/33446260
http://dx.doi.org/10.1186/s13059-020-02250-6

Ejemplares similares

Ejemplares similares