Cargando…

Systematic Evaluations of Doxorubicin-Induced Toxicity in Rats Based on Metabolomics

[Image: see text] Doxorubicin (DOX) is widely used to treat solid tumors, but its use is limited by its severe cardiotoxicity, nephrotoxicity, hepatotoxicity, and neurotoxicity. Metabolomic studies on DOX-induced toxicity are mainly focused on alterations in the heart and kidney, but systematic rese...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geng, Chunmei, Cui, Changmeng, Wang, Changshui, Lu, Shuxin, Zhang, Maokun, Chen, Dan, Jiang, Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807767/ https://www.ncbi.nlm.nih.gov/pubmed/33458487 http://dx.doi.org/10.1021/acsomega.0c04677

Ejemplares similares

Comprehensive Evaluation of Lipopolysaccharide-Induced Changes in Rats Based on Metabolomics
por: Geng, Chunmei, et al.
Publicado: (2020)

Metabolomic Profiling Revealed Potential Biomarkers in Patients With Moyamoya Disease
por: Geng, Chunmei, et al.
Publicado: (2020)

A GC–MS-based untargeted metabolomics approach for comprehensive metabolic profiling of vancomycin-induced toxicity in mice
por: Cui, Changmeng, et al.
Publicado: (2022)

Systematic impacts of chronic unpredictable mild stress on metabolomics in rats
por: Geng, Chunmei, et al.
Publicado: (2020)

Activation of angiotensin‐converting enzyme 2/angiotensin (1–7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling
por: Dang, Ruili, et al.
Publicado: (2021)

Impact of a long‐term high‐fructose diet on systemic metabolic profiles of mice
por: Cui, Changmeng, et al.
Publicado: (2022)

Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system
por: Cui, Changmeng, et al.
Publicado: (2019)

Association of Brain-Gut Peptides with Inflammatory Cytokines in Moyamoya Disease
por: Han, Wenxiu, et al.
Publicado: (2020)

Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism
por: Cui, Changmeng, et al.
Publicado: (2021)

Comprehensive Analysis of Metabolic Changes in Male Mice Exposed to Sodium Valproate Based on GC-MS Analysis
por: Gao, Yahao, et al.
Publicado: (2022)

Systematic Metabolic Profiling of Mice with Dextran Sulfate Sodium-Induced Colitis
por: Xie, Dadi, et al.
Publicado: (2021)

New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival
por: Gao, Yahao, et al.
Publicado: (2022)

LCZ696 ameliorates doxorubicin-induced cardiomyocyte toxicity in rats
por: Miyoshi, Toru, et al.
Publicado: (2022)

Doxorubicin-induced ovarian toxicity
por: Ben-Aharon, Irit, et al.
Publicado: (2010)

Cerebral endothelial cell-derived extracellular vesicles regulate microglial polarization and promote autophagy via delivery of miR-672-5p
por: Wang, Changshui, et al.
Publicado: (2023)

A Metabolomic Study of Rats with Doxorubicin-Induced Cardiomyopathy and Shengmai Injection Treatment
por: Chen, Yu, et al.
Publicado: (2015)

Cardioprotective effect of ascorbic acid on doxorubicin-induced myocardial toxicity in rats
por: Viswanatha Swamy, A.H.M., et al.
Publicado: (2011)

The Efficacy of Amifostine against Multiple-Dose Doxorubicin-Induced Toxicity in Rats
por: Jaćević, Vesna, et al.
Publicado: (2018)

Therapeutic effect of valsartan against doxorubicin-induced renal toxicity in rats
por: Liu, Hai-Xia, et al.
Publicado: (2019)

Cardioprotective Effect of Quercetin and Sitagliptin in Doxorubicin-Induced Cardiac Toxicity in Rats
por: Aziz, Tavga Ahmed
Publicado: (2021)

Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats
por: Hosseini, Azar, et al.
Publicado: (2022)

Exploration the Mechanism of Doxorubicin-Induced Heart Failure in Rats by Integration of Proteomics and Metabolomics Data
por: Yuan, Yu, et al.
Publicado: (2020)

Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats
por: Swamy, Agadihiremath Vishwanatha, et al.
Publicado: (2012)

Protective role of Phyllantus niruri extract in doxorubicin-induced myocardial toxicity in rats
por: Thippeswamy, A.H.M., et al.
Publicado: (2011)

Korean Red Ginseng enhances cardiac hemodynamics on doxorubicin-induced toxicity in rats
por: Jang, Young-Jin, et al.
Publicado: (2020)

Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats
por: Ahmed, Zheen Aorahman, et al.
Publicado: (2019)

Evaluation of age effects on doxorubicin-induced toxicity in mesenchymal stem cells
por: Bashiri Dezfouli, Ali, et al.
Publicado: (2017)

RNF213 gene silencing upregulates transforming growth factor β1 expression in bone marrow-derived mesenchymal stem cells and is involved in the onset of Moyamoya disease
por: Wang, Changshui, et al.
Publicado: (2021)

Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms
por: Kim, Hyung Min, et al.
Publicado: (2021)

Evaluation of biomarkers for doxorubicin‑induced cardiac injury in rats
por: Pan, Dong-Sheng, et al.
Publicado: (2022)

Metabolic Effects of Doxorubicin on the Rat Liver Assessed With Hyperpolarized MRI and Metabolomics
por: Timm, Kerstin N., et al.
Publicado: (2022)

Association of leptin and leptin receptor polymorphisms with coronary artery disease in a North Chinese Han population
por: Wang, Haidong, et al.
Publicado: (2020)

In vivo Studies on the Protective Effect of Propolis on Doxorubicin-Induced Toxicity in Liver of Male Rats
por: Singla, Shivani, et al.
Publicado: (2014)

Antioxidant Effects of Aerobic Training and Crocin Consumption on Doxorubicin-Induced Testicular Toxicity in Rats
por: Davoodi, Mohsen, et al.
Publicado: (2021)

Effects of Exercise Preconditioning on Doxorubicin-Induced Liver and Kidney Toxicity in Male and Female Rats
por: Boeno, Franccesco P., et al.
Publicado: (2023)

Doxorubicin-induced cardiovascular toxicity: a longitudinal evaluation of functional and molecular markers
por: Bosman, Matthias, et al.
Publicado: (2023)

Deposition of Doxorubicin in Rats following Administration of Three Newly Synthesized Doxorubicin Conjugates
por: Huan, Menglei, et al.
Publicado: (2013)

Systematic assessment of streptozotocin-induced diabetic metabolic alterations in rats using metabolomics
por: Si, Qingying, et al.
Publicado: (2023)

Protective Effects of Dexrazoxane against Doxorubicin-Induced Cardiotoxicity: A Metabolomic Study
por: QuanJun, Yang, et al.
Publicado: (2017)

Vitamin D Receptor Activation Influences NADPH Oxidase (NOX(2)) Activity and Protects against Neurological Deficits and Apoptosis in a Rat Model of Traumatic Brain Injury
por: Cui, Changmeng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ja3k69l1ggsmfr1ba98fckdb3b