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Development of BODIPY FL VH032 as a High-Affinity and Selective von Hippel–Lindau E3 Ligase Fluorescent Probe and Its Application in a Time-Resolved Fluorescence Resonance Energy-Transfer Assay
[Image: see text] The von Hippel–Lindau (VHL) tumor suppressor associates with transcription factors elongin-C and elongin-B to form the VHL–elongin-C–elongin-B protein complex and carry out its functions, such as degradation of hypoxia-inducible factors. VHL ligands are used not only to modulate hy...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807814/ https://www.ncbi.nlm.nih.gov/pubmed/33458521 http://dx.doi.org/10.1021/acsomega.0c05221 |