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Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression

BACKGROUND: Dyslipidemia contributes to the development and progression of arterial stiffness. We aimed to identify the most informative measures of serum lipids and their calculated ratios in terms of arterial stiffness progression risk. METHODS: Total cholesterol (TC), triglyceride (TG), low-densi...

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Autores principales: Sang, Yu, Cao, Ming, Wu, Xiaofen, Ruan, Lei, Zhang, Cuntai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807880/
https://www.ncbi.nlm.nih.gov/pubmed/33441079
http://dx.doi.org/10.1186/s12872-020-01846-x
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author Sang, Yu
Cao, Ming
Wu, Xiaofen
Ruan, Lei
Zhang, Cuntai
author_facet Sang, Yu
Cao, Ming
Wu, Xiaofen
Ruan, Lei
Zhang, Cuntai
author_sort Sang, Yu
collection PubMed
description BACKGROUND: Dyslipidemia contributes to the development and progression of arterial stiffness. We aimed to identify the most informative measures of serum lipids and their calculated ratios in terms of arterial stiffness progression risk. METHODS: Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and brachial-ankle pulse wave velocity (baPWV) of 659 healthy males (47.4 ± 10.7 years) were measured at baseline. Values for non-HDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C were calculated. BaPWV was re-performed after 4.1 years follow-up. Elevated baPWV was defined as baPWV ≥ 1400 cm/s. RESULTS: Over the follow-up period, the mean baPWV value increased from 1340 cm/s to 1410 cm/s, and 331 individuals increased/persisted with high baPWV (outcome 1). Among the 448 subjects who had normal baseline baPWV, 100 incident elevated baPWV occurred (outcome 2). Only baseline logTG (OR 1.64 [95% CI: 1.14–2.37] for outcome 1; 1.89 [1.14–3.17] for outcome 2) and logTG/HDL-C (1.54 [1.15–2.10] for outcome 1; 1.60 [1.05–2.45] for outcome 2) were significantly associated with arterial stiffness progression after adjusting for confounding factors. Adding logTG or logTG/HDL-C to age and blood pressure improved the accuracy of risk predictions for arterial stiffness progression. These associations remained significant when lipids were analyzed as categorical variables. CONCLUSIONS: Baseline serum TG and TG/HDL-C were independently associated with increases in/persistently high baPWV and incident elevated baPWV, and they performed more effectively than other lipid variables in identifying healthy men at high risk of arterial stiffness progression.
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spelling pubmed-78078802021-01-15 Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression Sang, Yu Cao, Ming Wu, Xiaofen Ruan, Lei Zhang, Cuntai BMC Cardiovasc Disord Research Article BACKGROUND: Dyslipidemia contributes to the development and progression of arterial stiffness. We aimed to identify the most informative measures of serum lipids and their calculated ratios in terms of arterial stiffness progression risk. METHODS: Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and brachial-ankle pulse wave velocity (baPWV) of 659 healthy males (47.4 ± 10.7 years) were measured at baseline. Values for non-HDL-C, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C were calculated. BaPWV was re-performed after 4.1 years follow-up. Elevated baPWV was defined as baPWV ≥ 1400 cm/s. RESULTS: Over the follow-up period, the mean baPWV value increased from 1340 cm/s to 1410 cm/s, and 331 individuals increased/persisted with high baPWV (outcome 1). Among the 448 subjects who had normal baseline baPWV, 100 incident elevated baPWV occurred (outcome 2). Only baseline logTG (OR 1.64 [95% CI: 1.14–2.37] for outcome 1; 1.89 [1.14–3.17] for outcome 2) and logTG/HDL-C (1.54 [1.15–2.10] for outcome 1; 1.60 [1.05–2.45] for outcome 2) were significantly associated with arterial stiffness progression after adjusting for confounding factors. Adding logTG or logTG/HDL-C to age and blood pressure improved the accuracy of risk predictions for arterial stiffness progression. These associations remained significant when lipids were analyzed as categorical variables. CONCLUSIONS: Baseline serum TG and TG/HDL-C were independently associated with increases in/persistently high baPWV and incident elevated baPWV, and they performed more effectively than other lipid variables in identifying healthy men at high risk of arterial stiffness progression. BioMed Central 2021-01-13 /pmc/articles/PMC7807880/ /pubmed/33441079 http://dx.doi.org/10.1186/s12872-020-01846-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Sang, Yu
Cao, Ming
Wu, Xiaofen
Ruan, Lei
Zhang, Cuntai
Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression
title Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression
title_full Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression
title_fullStr Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression
title_full_unstemmed Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression
title_short Use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression
title_sort use of lipid parameters to identify apparently healthy men at high risk of arterial stiffness progression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807880/
https://www.ncbi.nlm.nih.gov/pubmed/33441079
http://dx.doi.org/10.1186/s12872-020-01846-x
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