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Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations

Selective serotonin reuptake inhibitors (SSRIs) are widely used in the treatment of many types of mental disorders. Citalopram is commonly used as a new generation of SSRIs in this regard; however, unfortunately, its overdose is associated with seizure and heart disorders. The reported case in the p...

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Autores principales: Zoofaghari, Shafeajafar, Wong, Anselm, Kiarasi, Pegah, Gheshlaghi, Farzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808186/
https://www.ncbi.nlm.nih.gov/pubmed/33489987
http://dx.doi.org/10.4103/jrpp.JRPP_20_24
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author Zoofaghari, Shafeajafar
Wong, Anselm
Kiarasi, Pegah
Gheshlaghi, Farzad
author_facet Zoofaghari, Shafeajafar
Wong, Anselm
Kiarasi, Pegah
Gheshlaghi, Farzad
author_sort Zoofaghari, Shafeajafar
collection PubMed
description Selective serotonin reuptake inhibitors (SSRIs) are widely used in the treatment of many types of mental disorders. Citalopram is commonly used as a new generation of SSRIs in this regard; however, unfortunately, its overdose is associated with seizure and heart disorders. The reported case in the present study indicated recurrent seizures, nonspecific ST-T changes, and prolonged QT interval due to the overuse of citalopram. The patient had bilateral anterior shoulder dislocation along with right proximal humerus fracture that was occurred during the seizure. The dislocation was initially reduced and then fixed. Moreover, the seizure was controlled with diazepam without any problems, and cardiac monitoring continued for 2 days. Massive citalopram overdose may be associated with recurrent seizures and QT prolongation. Complications postseizures, such as shoulder dislocations, should be examined for and managed appropriately.
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spelling pubmed-78081862021-01-22 Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations Zoofaghari, Shafeajafar Wong, Anselm Kiarasi, Pegah Gheshlaghi, Farzad J Res Pharm Pract Case Report Selective serotonin reuptake inhibitors (SSRIs) are widely used in the treatment of many types of mental disorders. Citalopram is commonly used as a new generation of SSRIs in this regard; however, unfortunately, its overdose is associated with seizure and heart disorders. The reported case in the present study indicated recurrent seizures, nonspecific ST-T changes, and prolonged QT interval due to the overuse of citalopram. The patient had bilateral anterior shoulder dislocation along with right proximal humerus fracture that was occurred during the seizure. The dislocation was initially reduced and then fixed. Moreover, the seizure was controlled with diazepam without any problems, and cardiac monitoring continued for 2 days. Massive citalopram overdose may be associated with recurrent seizures and QT prolongation. Complications postseizures, such as shoulder dislocations, should be examined for and managed appropriately. Wolters Kluwer - Medknow 2020-10-08 /pmc/articles/PMC7808186/ /pubmed/33489987 http://dx.doi.org/10.4103/jrpp.JRPP_20_24 Text en Copyright: © 2020 Journal of Research in Pharmacy Practice http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Zoofaghari, Shafeajafar
Wong, Anselm
Kiarasi, Pegah
Gheshlaghi, Farzad
Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations
title Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations
title_full Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations
title_fullStr Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations
title_full_unstemmed Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations
title_short Massive Citalopram Overdose Associated with Recurrent Seizures and Bilateral Shoulder Dislocations
title_sort massive citalopram overdose associated with recurrent seizures and bilateral shoulder dislocations
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808186/
https://www.ncbi.nlm.nih.gov/pubmed/33489987
http://dx.doi.org/10.4103/jrpp.JRPP_20_24
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