The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer’s disease

Genetic studies identified mutations in several immune-related genes that confer increased risk for developing Alzheimer’s disease (AD), suggesting a key role for microglia in AD pathology. Microglia are recruited to and actively modulate the local toxicity of amyloid plaques in models of AD through...

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Detalles Bibliográficos
Autores principales: von Saucken, Victoria E., Jay, Taylor R., Landreth, Gary E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808254/
https://www.ncbi.nlm.nih.gov/pubmed/32890775
http://dx.doi.org/10.1016/j.nbd.2020.105072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808254/
https://www.ncbi.nlm.nih.gov/pubmed/32890775
http://dx.doi.org/10.1016/j.nbd.2020.105072

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