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The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer’s disease
Genetic studies identified mutations in several immune-related genes that confer increased risk for developing Alzheimer’s disease (AD), suggesting a key role for microglia in AD pathology. Microglia are recruited to and actively modulate the local toxicity of amyloid plaques in models of AD through...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808254/ https://www.ncbi.nlm.nih.gov/pubmed/32890775 http://dx.doi.org/10.1016/j.nbd.2020.105072 |