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pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water

A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the...

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Detalles Bibliográficos
Autores principales: Wu, Long-Fei, Liu, Ziwei, Sutherland, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808311/
https://www.ncbi.nlm.nih.gov/pubmed/33242043
http://dx.doi.org/10.1039/d0cc06042a
Descripción
Sumario:A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the amide bond.