pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water

A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the...

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Detalles Bibliográficos
Autores principales: Wu, Long-Fei, Liu, Ziwei, Sutherland, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808311/
https://www.ncbi.nlm.nih.gov/pubmed/33242043
http://dx.doi.org/10.1039/d0cc06042a
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author Wu, Long-Fei
Liu, Ziwei
Sutherland, John D.
author_facet Wu, Long-Fei
Liu, Ziwei
Sutherland, John D.
author_sort Wu, Long-Fei
collection PubMed
description A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the amide bond.
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spelling pubmed-78083112021-01-22 pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water Wu, Long-Fei Liu, Ziwei Sutherland, John D. Chem Commun (Camb) Chemistry A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the amide bond. Royal Society of Chemistry 2021-01-04 2020-11-20 /pmc/articles/PMC7808311/ /pubmed/33242043 http://dx.doi.org/10.1039/d0cc06042a Text en This journal is © The Royal Society of Chemistry 2021 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Wu, Long-Fei
Liu, Ziwei
Sutherland, John D.
pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water
title pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water
title_full pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water
title_fullStr pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water
title_full_unstemmed pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water
title_short pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water
title_sort ph-dependent peptide bond formation by the selective coupling of α-amino acids in water
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808311/
https://www.ncbi.nlm.nih.gov/pubmed/33242043
http://dx.doi.org/10.1039/d0cc06042a
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AT liuziwei phdependentpeptidebondformationbytheselectivecouplingofaaminoacidsinwater
AT sutherlandjohnd phdependentpeptidebondformationbytheselectivecouplingofaaminoacidsinwater

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