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pH-Dependent peptide bond formation by the selective coupling of α-amino acids in water

A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the...

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Detalles Bibliográficos
Autores principales:	Wu, Long-Fei, Liu, Ziwei, Sutherland, John D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808311/ https://www.ncbi.nlm.nih.gov/pubmed/33242043 http://dx.doi.org/10.1039/d0cc06042a

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