Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

Intramuscular vaccination with ChAdOx1 nCoV-19/AZD1222 protected rhesus macaques against pneumonia but did not reduce shedding of SARS-CoV-2. Here we investigate whether intranasally administered ChAdOx1 nCoV-19 reduces shedding, using a SARS-CoV-2 virus with the D614G mutation in the spike protein....

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Detalles Bibliográficos
Autores principales: van Doremalen, Neeltje, Purushotham, Jyothi N., Schulz, Jonathan E., Holbrook, Myndi G., Bushmaker, Trenton, Carmody, Aaron, Port, Julia R., Yinda, Claude K., Okumura, Atsushi, Saturday, Greg, Amanat, Fatima, Krammer, Florian, Hanley, Patrick W., Smith, Brian J., Lovaglio, Jamie, Anzick, Sarah L., Barbian, Kent, Martens, Craig, Gilbert, Sarah, Lambe, Teresa, Munster, Vincent J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808328/
https://www.ncbi.nlm.nih.gov/pubmed/33447831
http://dx.doi.org/10.1101/2021.01.09.426058

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