The α2/α3GABA(A) receptor modulator TPA023B alleviates not only the sensory but also the tonic affective component of chronic pain in mice

Diminished synaptic inhibition in the spinal dorsal horn is a major contributor to pathological pain syndromes of neuropathic or inflammatory origin. Drugs that enhance the activity of dorsal horn α2/α3GABA(A)Rs normalize exaggerated nociceptive responses in rodents with neuropathic nerve lesions or...

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Detalles Bibliográficos
Autores principales: Neumann, Elena, Küpfer, Laura, Zeilhofer, Hanns Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808355/
https://www.ncbi.nlm.nih.gov/pubmed/32773599
http://dx.doi.org/10.1097/j.pain.0000000000002030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808355/
https://www.ncbi.nlm.nih.gov/pubmed/32773599
http://dx.doi.org/10.1097/j.pain.0000000000002030

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