Cargando…
The α2/α3GABA(A) receptor modulator TPA023B alleviates not only the sensory but also the tonic affective component of chronic pain in mice
Diminished synaptic inhibition in the spinal dorsal horn is a major contributor to pathological pain syndromes of neuropathic or inflammatory origin. Drugs that enhance the activity of dorsal horn α2/α3GABA(A)Rs normalize exaggerated nociceptive responses in rodents with neuropathic nerve lesions or...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Wolters Kluwer
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808355/ https://www.ncbi.nlm.nih.gov/pubmed/32773599 http://dx.doi.org/10.1097/j.pain.0000000000002030 |