Cargando…

Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials

BACKGROUND: Since the outbreak of coronavirus disease 2019 (COVID-19) in 2019, it has swept the world with rapid development and is one of the infectious diseases that seriously threatened global public health. Because of the complex pathogenesis, high infectivity, and high fatality rate of COVID-19...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Shasha, Zhang, Jingxia, Li, Fan, Mao, Ajuan, Li, Yajuan, Zhao, Chongbo, Hu, Xiaowei, Li, Fang, Wang, Weifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808524/
https://www.ncbi.nlm.nih.gov/pubmed/33466197
http://dx.doi.org/10.1097/MD.0000000000024204
_version_ 1783636917338767360
author Li, Shasha
Zhang, Jingxia
Li, Fan
Mao, Ajuan
Li, Yajuan
Zhao, Chongbo
Hu, Xiaowei
Li, Fang
Wang, Weifeng
author_facet Li, Shasha
Zhang, Jingxia
Li, Fan
Mao, Ajuan
Li, Yajuan
Zhao, Chongbo
Hu, Xiaowei
Li, Fang
Wang, Weifeng
author_sort Li, Shasha
collection PubMed
description BACKGROUND: Since the outbreak of coronavirus disease 2019 (COVID-19) in 2019, it has swept the world with rapid development and is one of the infectious diseases that seriously threatened global public health. Because of the complex pathogenesis, high infectivity, and high fatality rate of COVID-19, there are no effective treatments for this epidemic at present. Traditional Chinese Medicine (TCM) has a long clinical history in the prevention and treatment of such acute infectious diseases. The therapeutic effect of Lianhua Qingwen (LHQW) on this new coronary pneumonia has attracted the attention of all walks of life, and relevant research reports continue to appear. Here, we intend to conduct a systematic review and meta-analysis of randomized controlled trials (RCT) to evaluate the efficacy of LHQW in COVID-19 patients. METHODS: We will search each database from the built-in until Dec 2020. The English literature mainly search the Cochrane Library, EMBASE, PubMed, and Web of Science, while the Chinese literature come from CNKI, VIP, Chinese Biomedical Database (CBM), Chinese Science Citation Database (CSCD), and Wan Fang database. Simultaneously, we will retrieve clinical registration tests. This study only screens the RCT of LHQW against COVID-19 and evaluates its efficacy and safety. We will use the Cochrane Handbook to systematically review interventions to assess the risk of bias. The protocol will be reported according to the approach and preferred report items for systematic review and meta-analysis protocols (PRISMA - P). Finally, RevMan software version 5.3 will be used for meta-analysis. RESULTS: The systematic review and meta-analysis aim to review and pool current clinical outcomes of LHQW for treating COVID-19. CONCLUSION: This study will provide further evidence for the efficacy and safety of LHQW in the treatment of COVID-19. INPLASY REGISTRATION NUMBER: INPLASY2020120043.
format Online
Article
Text
id pubmed-7808524
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-78085242021-01-21 Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials Li, Shasha Zhang, Jingxia Li, Fan Mao, Ajuan Li, Yajuan Zhao, Chongbo Hu, Xiaowei Li, Fang Wang, Weifeng Medicine (Baltimore) 3800 BACKGROUND: Since the outbreak of coronavirus disease 2019 (COVID-19) in 2019, it has swept the world with rapid development and is one of the infectious diseases that seriously threatened global public health. Because of the complex pathogenesis, high infectivity, and high fatality rate of COVID-19, there are no effective treatments for this epidemic at present. Traditional Chinese Medicine (TCM) has a long clinical history in the prevention and treatment of such acute infectious diseases. The therapeutic effect of Lianhua Qingwen (LHQW) on this new coronary pneumonia has attracted the attention of all walks of life, and relevant research reports continue to appear. Here, we intend to conduct a systematic review and meta-analysis of randomized controlled trials (RCT) to evaluate the efficacy of LHQW in COVID-19 patients. METHODS: We will search each database from the built-in until Dec 2020. The English literature mainly search the Cochrane Library, EMBASE, PubMed, and Web of Science, while the Chinese literature come from CNKI, VIP, Chinese Biomedical Database (CBM), Chinese Science Citation Database (CSCD), and Wan Fang database. Simultaneously, we will retrieve clinical registration tests. This study only screens the RCT of LHQW against COVID-19 and evaluates its efficacy and safety. We will use the Cochrane Handbook to systematically review interventions to assess the risk of bias. The protocol will be reported according to the approach and preferred report items for systematic review and meta-analysis protocols (PRISMA - P). Finally, RevMan software version 5.3 will be used for meta-analysis. RESULTS: The systematic review and meta-analysis aim to review and pool current clinical outcomes of LHQW for treating COVID-19. CONCLUSION: This study will provide further evidence for the efficacy and safety of LHQW in the treatment of COVID-19. INPLASY REGISTRATION NUMBER: INPLASY2020120043. Lippincott Williams & Wilkins 2021-01-15 /pmc/articles/PMC7808524/ /pubmed/33466197 http://dx.doi.org/10.1097/MD.0000000000024204 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 3800
Li, Shasha
Zhang, Jingxia
Li, Fan
Mao, Ajuan
Li, Yajuan
Zhao, Chongbo
Hu, Xiaowei
Li, Fang
Wang, Weifeng
Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials
title Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials
title_full Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials
title_fullStr Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials
title_full_unstemmed Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials
title_short Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials
title_sort traditional chinese medicine lianhua qingwen for treating covid-19: a protocol for a meta-analysis and systematic review of randomized controlled trials
topic 3800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808524/
https://www.ncbi.nlm.nih.gov/pubmed/33466197
http://dx.doi.org/10.1097/MD.0000000000024204
work_keys_str_mv AT lishasha traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials
AT zhangjingxia traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials
AT lifan traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials
AT maoajuan traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials
AT liyajuan traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials
AT zhaochongbo traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials
AT huxiaowei traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials
AT lifang traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials
AT wangweifeng traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials