Cargando…
Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials
BACKGROUND: Since the outbreak of coronavirus disease 2019 (COVID-19) in 2019, it has swept the world with rapid development and is one of the infectious diseases that seriously threatened global public health. Because of the complex pathogenesis, high infectivity, and high fatality rate of COVID-19...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808524/ https://www.ncbi.nlm.nih.gov/pubmed/33466197 http://dx.doi.org/10.1097/MD.0000000000024204 |
_version_ | 1783636917338767360 |
---|---|
author | Li, Shasha Zhang, Jingxia Li, Fan Mao, Ajuan Li, Yajuan Zhao, Chongbo Hu, Xiaowei Li, Fang Wang, Weifeng |
author_facet | Li, Shasha Zhang, Jingxia Li, Fan Mao, Ajuan Li, Yajuan Zhao, Chongbo Hu, Xiaowei Li, Fang Wang, Weifeng |
author_sort | Li, Shasha |
collection | PubMed |
description | BACKGROUND: Since the outbreak of coronavirus disease 2019 (COVID-19) in 2019, it has swept the world with rapid development and is one of the infectious diseases that seriously threatened global public health. Because of the complex pathogenesis, high infectivity, and high fatality rate of COVID-19, there are no effective treatments for this epidemic at present. Traditional Chinese Medicine (TCM) has a long clinical history in the prevention and treatment of such acute infectious diseases. The therapeutic effect of Lianhua Qingwen (LHQW) on this new coronary pneumonia has attracted the attention of all walks of life, and relevant research reports continue to appear. Here, we intend to conduct a systematic review and meta-analysis of randomized controlled trials (RCT) to evaluate the efficacy of LHQW in COVID-19 patients. METHODS: We will search each database from the built-in until Dec 2020. The English literature mainly search the Cochrane Library, EMBASE, PubMed, and Web of Science, while the Chinese literature come from CNKI, VIP, Chinese Biomedical Database (CBM), Chinese Science Citation Database (CSCD), and Wan Fang database. Simultaneously, we will retrieve clinical registration tests. This study only screens the RCT of LHQW against COVID-19 and evaluates its efficacy and safety. We will use the Cochrane Handbook to systematically review interventions to assess the risk of bias. The protocol will be reported according to the approach and preferred report items for systematic review and meta-analysis protocols (PRISMA - P). Finally, RevMan software version 5.3 will be used for meta-analysis. RESULTS: The systematic review and meta-analysis aim to review and pool current clinical outcomes of LHQW for treating COVID-19. CONCLUSION: This study will provide further evidence for the efficacy and safety of LHQW in the treatment of COVID-19. INPLASY REGISTRATION NUMBER: INPLASY2020120043. |
format | Online Article Text |
id | pubmed-7808524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-78085242021-01-21 Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials Li, Shasha Zhang, Jingxia Li, Fan Mao, Ajuan Li, Yajuan Zhao, Chongbo Hu, Xiaowei Li, Fang Wang, Weifeng Medicine (Baltimore) 3800 BACKGROUND: Since the outbreak of coronavirus disease 2019 (COVID-19) in 2019, it has swept the world with rapid development and is one of the infectious diseases that seriously threatened global public health. Because of the complex pathogenesis, high infectivity, and high fatality rate of COVID-19, there are no effective treatments for this epidemic at present. Traditional Chinese Medicine (TCM) has a long clinical history in the prevention and treatment of such acute infectious diseases. The therapeutic effect of Lianhua Qingwen (LHQW) on this new coronary pneumonia has attracted the attention of all walks of life, and relevant research reports continue to appear. Here, we intend to conduct a systematic review and meta-analysis of randomized controlled trials (RCT) to evaluate the efficacy of LHQW in COVID-19 patients. METHODS: We will search each database from the built-in until Dec 2020. The English literature mainly search the Cochrane Library, EMBASE, PubMed, and Web of Science, while the Chinese literature come from CNKI, VIP, Chinese Biomedical Database (CBM), Chinese Science Citation Database (CSCD), and Wan Fang database. Simultaneously, we will retrieve clinical registration tests. This study only screens the RCT of LHQW against COVID-19 and evaluates its efficacy and safety. We will use the Cochrane Handbook to systematically review interventions to assess the risk of bias. The protocol will be reported according to the approach and preferred report items for systematic review and meta-analysis protocols (PRISMA - P). Finally, RevMan software version 5.3 will be used for meta-analysis. RESULTS: The systematic review and meta-analysis aim to review and pool current clinical outcomes of LHQW for treating COVID-19. CONCLUSION: This study will provide further evidence for the efficacy and safety of LHQW in the treatment of COVID-19. INPLASY REGISTRATION NUMBER: INPLASY2020120043. Lippincott Williams & Wilkins 2021-01-15 /pmc/articles/PMC7808524/ /pubmed/33466197 http://dx.doi.org/10.1097/MD.0000000000024204 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | 3800 Li, Shasha Zhang, Jingxia Li, Fan Mao, Ajuan Li, Yajuan Zhao, Chongbo Hu, Xiaowei Li, Fang Wang, Weifeng Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials |
title | Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials |
title_full | Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials |
title_fullStr | Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials |
title_full_unstemmed | Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials |
title_short | Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials |
title_sort | traditional chinese medicine lianhua qingwen for treating covid-19: a protocol for a meta-analysis and systematic review of randomized controlled trials |
topic | 3800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808524/ https://www.ncbi.nlm.nih.gov/pubmed/33466197 http://dx.doi.org/10.1097/MD.0000000000024204 |
work_keys_str_mv | AT lishasha traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT zhangjingxia traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT lifan traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT maoajuan traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT liyajuan traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT zhaochongbo traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT huxiaowei traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT lifang traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials AT wangweifeng traditionalchinesemedicinelianhuaqingwenfortreatingcovid19aprotocolforametaanalysisandsystematicreviewofrandomizedcontrolledtrials |