Cargando…

Successful Treatment of Refractory Autoimmune Enteropathy With Ustekinumab

Autoimmune enteropathy (AIE) is a rare autoimmune disorder that has been described both in pediatric and adult patients and usually causes intractable watery diarrhea. The management of AIE is not standardized because the disease shows variable response to different immunosuppressive regimens includ...

Descripción completa

Detalles Bibliográficos
Autores principales: Scheid, Johannes F., Misdraji, Joseph, Nath, Barbara J., Yarze, Joseph C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808559/
https://www.ncbi.nlm.nih.gov/pubmed/33457439
http://dx.doi.org/10.14309/crj.0000000000000520
_version_ 1783636924695576576
author Scheid, Johannes F.
Misdraji, Joseph
Nath, Barbara J.
Yarze, Joseph C.
author_facet Scheid, Johannes F.
Misdraji, Joseph
Nath, Barbara J.
Yarze, Joseph C.
author_sort Scheid, Johannes F.
collection PubMed
description Autoimmune enteropathy (AIE) is a rare autoimmune disorder that has been described both in pediatric and adult patients and usually causes intractable watery diarrhea. The management of AIE is not standardized because the disease shows variable response to different immunosuppressive regimens including corticosteroids, azathioprine, cyclophosphamide, 6-mercaptopurine, tacrolimus, cyclosporine-A, infliximab, vedolizumab, and abatacept. We present a patient with adult-onset AIE and intractable high-volume diarrhea resulting in numerous hospitalizations and temporary parenteral nutrition, who is now successfully maintained on ustekinumab. Therefore, ustekinumab should be considered for further evaluation as a therapeutic option in cases of refractory AIE.
format Online
Article
Text
id pubmed-7808559
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Wolters Kluwer
record_format MEDLINE/PubMed
spelling pubmed-78085592021-01-15 Successful Treatment of Refractory Autoimmune Enteropathy With Ustekinumab Scheid, Johannes F. Misdraji, Joseph Nath, Barbara J. Yarze, Joseph C. ACG Case Rep J Case Report Autoimmune enteropathy (AIE) is a rare autoimmune disorder that has been described both in pediatric and adult patients and usually causes intractable watery diarrhea. The management of AIE is not standardized because the disease shows variable response to different immunosuppressive regimens including corticosteroids, azathioprine, cyclophosphamide, 6-mercaptopurine, tacrolimus, cyclosporine-A, infliximab, vedolizumab, and abatacept. We present a patient with adult-onset AIE and intractable high-volume diarrhea resulting in numerous hospitalizations and temporary parenteral nutrition, who is now successfully maintained on ustekinumab. Therefore, ustekinumab should be considered for further evaluation as a therapeutic option in cases of refractory AIE. Wolters Kluwer 2021-01-13 /pmc/articles/PMC7808559/ /pubmed/33457439 http://dx.doi.org/10.14309/crj.0000000000000520 Text en © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Scheid, Johannes F.
Misdraji, Joseph
Nath, Barbara J.
Yarze, Joseph C.
Successful Treatment of Refractory Autoimmune Enteropathy With Ustekinumab
title Successful Treatment of Refractory Autoimmune Enteropathy With Ustekinumab
title_full Successful Treatment of Refractory Autoimmune Enteropathy With Ustekinumab
title_fullStr Successful Treatment of Refractory Autoimmune Enteropathy With Ustekinumab
title_full_unstemmed Successful Treatment of Refractory Autoimmune Enteropathy With Ustekinumab
title_short Successful Treatment of Refractory Autoimmune Enteropathy With Ustekinumab
title_sort successful treatment of refractory autoimmune enteropathy with ustekinumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808559/
https://www.ncbi.nlm.nih.gov/pubmed/33457439
http://dx.doi.org/10.14309/crj.0000000000000520
work_keys_str_mv AT scheidjohannesf successfultreatmentofrefractoryautoimmuneenteropathywithustekinumab
AT misdrajijoseph successfultreatmentofrefractoryautoimmuneenteropathywithustekinumab
AT nathbarbaraj successfultreatmentofrefractoryautoimmuneenteropathywithustekinumab
AT yarzejosephc successfultreatmentofrefractoryautoimmuneenteropathywithustekinumab