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Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia

In this study, we examined the role of the eastern bent-winged bat (Miniopterus fuliginosus) in the dispersion of bat adenovirus and bat alphacoronavirus in east Asia, considering their gene flows and divergence times (based on deep-sequencing data), using bat fecal guano samples. Bats in China move...

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Autores principales: Kimprasit, Thachawech, Nunome, Mitsuo, Iida, Keisuke, Murakami, Yoshitaka, Wong, Min-Liang, Wu, Chung-Hsin, Kobayashi, Ryosuke, Hengjan, Yupadee, Takemae, Hitoshi, Yonemitsu, Kenzo, Kuwata, Ryusei, Shimoda, Hiroshi, Si, Lifan, Sohn, Joon-Hyuk, Asakawa, Susumu, Ichiyanagi, Kenji, Maeda, Ken, Oh, Hong-Shik, Mizutani, Tetsuya, Kimura, Junpei, Iida, Atsuo, Hondo, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808576/
https://www.ncbi.nlm.nih.gov/pubmed/33444317
http://dx.doi.org/10.1371/journal.pone.0244006
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author Kimprasit, Thachawech
Nunome, Mitsuo
Iida, Keisuke
Murakami, Yoshitaka
Wong, Min-Liang
Wu, Chung-Hsin
Kobayashi, Ryosuke
Hengjan, Yupadee
Takemae, Hitoshi
Yonemitsu, Kenzo
Kuwata, Ryusei
Shimoda, Hiroshi
Si, Lifan
Sohn, Joon-Hyuk
Asakawa, Susumu
Ichiyanagi, Kenji
Maeda, Ken
Oh, Hong-Shik
Mizutani, Tetsuya
Kimura, Junpei
Iida, Atsuo
Hondo, Eiichi
author_facet Kimprasit, Thachawech
Nunome, Mitsuo
Iida, Keisuke
Murakami, Yoshitaka
Wong, Min-Liang
Wu, Chung-Hsin
Kobayashi, Ryosuke
Hengjan, Yupadee
Takemae, Hitoshi
Yonemitsu, Kenzo
Kuwata, Ryusei
Shimoda, Hiroshi
Si, Lifan
Sohn, Joon-Hyuk
Asakawa, Susumu
Ichiyanagi, Kenji
Maeda, Ken
Oh, Hong-Shik
Mizutani, Tetsuya
Kimura, Junpei
Iida, Atsuo
Hondo, Eiichi
author_sort Kimprasit, Thachawech
collection PubMed
description In this study, we examined the role of the eastern bent-winged bat (Miniopterus fuliginosus) in the dispersion of bat adenovirus and bat alphacoronavirus in east Asia, considering their gene flows and divergence times (based on deep-sequencing data), using bat fecal guano samples. Bats in China moved to Jeju Island and/or Taiwan in the last 20,000 years via the Korean Peninsula and/or Japan. The phylogenies of host mitochondrial D-loop DNA was not significantly congruent with those of bat adenovirus (m(2)(XY) = 0.07, p = 0.08), and bat alphacoronavirus (m(2)(XY) = 0.48, p = 0.20). We estimate that the first divergence time of bats carrying bat adenovirus in five caves studied (designated as K1, K2, JJ, N2, and F3) occurred approximately 3.17 million years ago. In contrast, the first divergence time of bat adenovirus among bats in the 5 caves was estimated to be approximately 224.32 years ago. The first divergence time of bats in caves CH, JJ, WY, N2, F1, F2, and F3 harboring bat alphacoronavirus was estimated to be 1.59 million years ago. The first divergence time of bat alphacoronavirus among the 7 caves was estimated to be approximately 2,596.92 years ago. The origin of bat adenovirus remains unclear, whereas our findings suggest that bat alphacoronavirus originated in Japan. Surprisingly, bat adenovirus and bat alphacoronavirus appeared to diverge substantially over the last 100 years, even though our gene-flow data indicate that the eastern bent-winged bat serves as an important natural reservoir of both viruses.
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spelling pubmed-78085762021-02-02 Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia Kimprasit, Thachawech Nunome, Mitsuo Iida, Keisuke Murakami, Yoshitaka Wong, Min-Liang Wu, Chung-Hsin Kobayashi, Ryosuke Hengjan, Yupadee Takemae, Hitoshi Yonemitsu, Kenzo Kuwata, Ryusei Shimoda, Hiroshi Si, Lifan Sohn, Joon-Hyuk Asakawa, Susumu Ichiyanagi, Kenji Maeda, Ken Oh, Hong-Shik Mizutani, Tetsuya Kimura, Junpei Iida, Atsuo Hondo, Eiichi PLoS One Research Article In this study, we examined the role of the eastern bent-winged bat (Miniopterus fuliginosus) in the dispersion of bat adenovirus and bat alphacoronavirus in east Asia, considering their gene flows and divergence times (based on deep-sequencing data), using bat fecal guano samples. Bats in China moved to Jeju Island and/or Taiwan in the last 20,000 years via the Korean Peninsula and/or Japan. The phylogenies of host mitochondrial D-loop DNA was not significantly congruent with those of bat adenovirus (m(2)(XY) = 0.07, p = 0.08), and bat alphacoronavirus (m(2)(XY) = 0.48, p = 0.20). We estimate that the first divergence time of bats carrying bat adenovirus in five caves studied (designated as K1, K2, JJ, N2, and F3) occurred approximately 3.17 million years ago. In contrast, the first divergence time of bat adenovirus among bats in the 5 caves was estimated to be approximately 224.32 years ago. The first divergence time of bats in caves CH, JJ, WY, N2, F1, F2, and F3 harboring bat alphacoronavirus was estimated to be 1.59 million years ago. The first divergence time of bat alphacoronavirus among the 7 caves was estimated to be approximately 2,596.92 years ago. The origin of bat adenovirus remains unclear, whereas our findings suggest that bat alphacoronavirus originated in Japan. Surprisingly, bat adenovirus and bat alphacoronavirus appeared to diverge substantially over the last 100 years, even though our gene-flow data indicate that the eastern bent-winged bat serves as an important natural reservoir of both viruses. Public Library of Science 2021-01-14 /pmc/articles/PMC7808576/ /pubmed/33444317 http://dx.doi.org/10.1371/journal.pone.0244006 Text en © 2021 Kimprasit et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kimprasit, Thachawech
Nunome, Mitsuo
Iida, Keisuke
Murakami, Yoshitaka
Wong, Min-Liang
Wu, Chung-Hsin
Kobayashi, Ryosuke
Hengjan, Yupadee
Takemae, Hitoshi
Yonemitsu, Kenzo
Kuwata, Ryusei
Shimoda, Hiroshi
Si, Lifan
Sohn, Joon-Hyuk
Asakawa, Susumu
Ichiyanagi, Kenji
Maeda, Ken
Oh, Hong-Shik
Mizutani, Tetsuya
Kimura, Junpei
Iida, Atsuo
Hondo, Eiichi
Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia
title Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia
title_full Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia
title_fullStr Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia
title_full_unstemmed Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia
title_short Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia
title_sort dispersal history of miniopterus fuliginosus bats and their associated viruses in east asia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808576/
https://www.ncbi.nlm.nih.gov/pubmed/33444317
http://dx.doi.org/10.1371/journal.pone.0244006
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