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Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia
In this study, we examined the role of the eastern bent-winged bat (Miniopterus fuliginosus) in the dispersion of bat adenovirus and bat alphacoronavirus in east Asia, considering their gene flows and divergence times (based on deep-sequencing data), using bat fecal guano samples. Bats in China move...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808576/ https://www.ncbi.nlm.nih.gov/pubmed/33444317 http://dx.doi.org/10.1371/journal.pone.0244006 |
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author | Kimprasit, Thachawech Nunome, Mitsuo Iida, Keisuke Murakami, Yoshitaka Wong, Min-Liang Wu, Chung-Hsin Kobayashi, Ryosuke Hengjan, Yupadee Takemae, Hitoshi Yonemitsu, Kenzo Kuwata, Ryusei Shimoda, Hiroshi Si, Lifan Sohn, Joon-Hyuk Asakawa, Susumu Ichiyanagi, Kenji Maeda, Ken Oh, Hong-Shik Mizutani, Tetsuya Kimura, Junpei Iida, Atsuo Hondo, Eiichi |
author_facet | Kimprasit, Thachawech Nunome, Mitsuo Iida, Keisuke Murakami, Yoshitaka Wong, Min-Liang Wu, Chung-Hsin Kobayashi, Ryosuke Hengjan, Yupadee Takemae, Hitoshi Yonemitsu, Kenzo Kuwata, Ryusei Shimoda, Hiroshi Si, Lifan Sohn, Joon-Hyuk Asakawa, Susumu Ichiyanagi, Kenji Maeda, Ken Oh, Hong-Shik Mizutani, Tetsuya Kimura, Junpei Iida, Atsuo Hondo, Eiichi |
author_sort | Kimprasit, Thachawech |
collection | PubMed |
description | In this study, we examined the role of the eastern bent-winged bat (Miniopterus fuliginosus) in the dispersion of bat adenovirus and bat alphacoronavirus in east Asia, considering their gene flows and divergence times (based on deep-sequencing data), using bat fecal guano samples. Bats in China moved to Jeju Island and/or Taiwan in the last 20,000 years via the Korean Peninsula and/or Japan. The phylogenies of host mitochondrial D-loop DNA was not significantly congruent with those of bat adenovirus (m(2)(XY) = 0.07, p = 0.08), and bat alphacoronavirus (m(2)(XY) = 0.48, p = 0.20). We estimate that the first divergence time of bats carrying bat adenovirus in five caves studied (designated as K1, K2, JJ, N2, and F3) occurred approximately 3.17 million years ago. In contrast, the first divergence time of bat adenovirus among bats in the 5 caves was estimated to be approximately 224.32 years ago. The first divergence time of bats in caves CH, JJ, WY, N2, F1, F2, and F3 harboring bat alphacoronavirus was estimated to be 1.59 million years ago. The first divergence time of bat alphacoronavirus among the 7 caves was estimated to be approximately 2,596.92 years ago. The origin of bat adenovirus remains unclear, whereas our findings suggest that bat alphacoronavirus originated in Japan. Surprisingly, bat adenovirus and bat alphacoronavirus appeared to diverge substantially over the last 100 years, even though our gene-flow data indicate that the eastern bent-winged bat serves as an important natural reservoir of both viruses. |
format | Online Article Text |
id | pubmed-7808576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-78085762021-02-02 Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia Kimprasit, Thachawech Nunome, Mitsuo Iida, Keisuke Murakami, Yoshitaka Wong, Min-Liang Wu, Chung-Hsin Kobayashi, Ryosuke Hengjan, Yupadee Takemae, Hitoshi Yonemitsu, Kenzo Kuwata, Ryusei Shimoda, Hiroshi Si, Lifan Sohn, Joon-Hyuk Asakawa, Susumu Ichiyanagi, Kenji Maeda, Ken Oh, Hong-Shik Mizutani, Tetsuya Kimura, Junpei Iida, Atsuo Hondo, Eiichi PLoS One Research Article In this study, we examined the role of the eastern bent-winged bat (Miniopterus fuliginosus) in the dispersion of bat adenovirus and bat alphacoronavirus in east Asia, considering their gene flows and divergence times (based on deep-sequencing data), using bat fecal guano samples. Bats in China moved to Jeju Island and/or Taiwan in the last 20,000 years via the Korean Peninsula and/or Japan. The phylogenies of host mitochondrial D-loop DNA was not significantly congruent with those of bat adenovirus (m(2)(XY) = 0.07, p = 0.08), and bat alphacoronavirus (m(2)(XY) = 0.48, p = 0.20). We estimate that the first divergence time of bats carrying bat adenovirus in five caves studied (designated as K1, K2, JJ, N2, and F3) occurred approximately 3.17 million years ago. In contrast, the first divergence time of bat adenovirus among bats in the 5 caves was estimated to be approximately 224.32 years ago. The first divergence time of bats in caves CH, JJ, WY, N2, F1, F2, and F3 harboring bat alphacoronavirus was estimated to be 1.59 million years ago. The first divergence time of bat alphacoronavirus among the 7 caves was estimated to be approximately 2,596.92 years ago. The origin of bat adenovirus remains unclear, whereas our findings suggest that bat alphacoronavirus originated in Japan. Surprisingly, bat adenovirus and bat alphacoronavirus appeared to diverge substantially over the last 100 years, even though our gene-flow data indicate that the eastern bent-winged bat serves as an important natural reservoir of both viruses. Public Library of Science 2021-01-14 /pmc/articles/PMC7808576/ /pubmed/33444317 http://dx.doi.org/10.1371/journal.pone.0244006 Text en © 2021 Kimprasit et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kimprasit, Thachawech Nunome, Mitsuo Iida, Keisuke Murakami, Yoshitaka Wong, Min-Liang Wu, Chung-Hsin Kobayashi, Ryosuke Hengjan, Yupadee Takemae, Hitoshi Yonemitsu, Kenzo Kuwata, Ryusei Shimoda, Hiroshi Si, Lifan Sohn, Joon-Hyuk Asakawa, Susumu Ichiyanagi, Kenji Maeda, Ken Oh, Hong-Shik Mizutani, Tetsuya Kimura, Junpei Iida, Atsuo Hondo, Eiichi Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia |
title | Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia |
title_full | Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia |
title_fullStr | Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia |
title_full_unstemmed | Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia |
title_short | Dispersal history of Miniopterus fuliginosus bats and their associated viruses in east Asia |
title_sort | dispersal history of miniopterus fuliginosus bats and their associated viruses in east asia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808576/ https://www.ncbi.nlm.nih.gov/pubmed/33444317 http://dx.doi.org/10.1371/journal.pone.0244006 |
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