Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster

Genome association studies in human and genetic studies in mouse implicated members of the transmembrane protein 132 (TMEM132) family in multiple conditions including panic disorder, hearing loss, limb and kidney malformation. However, the presence of five TMEM132 paralogs in mammalian genomes makes...

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Detalles Bibliográficos
Autores principales: Chon, Cristin, Chon, Grace, Matsui, Yurika, Zeng, Huiqing, Lai, Zhi-Chun, Liu, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808601/
https://www.ncbi.nlm.nih.gov/pubmed/33444382
http://dx.doi.org/10.1371/journal.pone.0245454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808601/
https://www.ncbi.nlm.nih.gov/pubmed/33444382
http://dx.doi.org/10.1371/journal.pone.0245454

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