Diminished cytokine-induced Jak/STAT signaling is associated with rheumatoid arthritis and disease activity

Rheumatoid arthritis (RA) is a systemic and incurable autoimmune disease characterized by chronic inflammation in synovial lining of joints. To identify the signaling pathways involved in RA, its disease activity, and treatment response, we adapted a systems immunology approach to simultaneously qua...

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Detalles Bibliográficos
Autores principales: Ptacek, Jason, Hawtin, Rachael E., Sun, Dongmei, Louie, Brent, Evensen, Erik, Mittleman, Barbara B., Cesano, Alessandra, Cavet, Guy, Bingham, Clifton O., Cofield, Stacey S., Curtis, Jeffrey R., Danila, Maria I., Raman, Chander, Furie, Richard A., Genovese, Mark C., Robinson, William H., Levesque, Marc C., Moreland, Larry W., Nigrovic, Peter A., Shadick, Nancy A., O’Dell, James R., Thiele, Geoffrey M., Clair, E. William St, Striebich, Christopher C., Hale, Matthew B., Khalili, Houman, Batliwalla, Franak, Aranow, Cynthia, Mackay, Meggan, Diamond, Betty, Nolan, Garry P., Gregersen, Peter K., Bridges, S. Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808603/
https://www.ncbi.nlm.nih.gov/pubmed/33444321
http://dx.doi.org/10.1371/journal.pone.0244187

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