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Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses

BACKGROUND: Polygenic risk scores (PRSs) can stratify populations into cardiovascular disease (CVD) risk groups. We aimed to quantify the potential advantage of adding information on PRSs to conventional risk factors in the primary prevention of CVD. METHODS AND FINDINGS: Using data from UK Biobank...

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Detalles Bibliográficos
Autores principales:	Sun, Luanluan, Pennells, Lisa, Kaptoge, Stephen, Nelson, Christopher P., Ritchie, Scott C., Abraham, Gad, Arnold, Matthew, Bell, Steven, Bolton, Thomas, Burgess, Stephen, Dudbridge, Frank, Guo, Qi, Sofianopoulou, Eleni, Stevens, David, Thompson, John R., Butterworth, Adam S., Wood, Angela, Danesh, John, Samani, Nilesh J., Inouye, Michael, Di Angelantonio, Emanuele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808664/ https://www.ncbi.nlm.nih.gov/pubmed/33444330 http://dx.doi.org/10.1371/journal.pmed.1003498

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