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Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F
[Image: see text] Two new ring-size-varying analogues (2 and 3) of ipomoeassin F were synthesized and evaluated. Improved cytotoxicity (IC(50): from 1.8 nM) and in vitro protein translocation inhibition (IC(50): 35 nM) derived from ring expansion imply that the binding pocket of Sec61α (isoform 1) c...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808706/ https://www.ncbi.nlm.nih.gov/pubmed/33264019 http://dx.doi.org/10.1021/acs.joc.0c01659 |