Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition

Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and novel compounds was evaluated using several human and...

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Detalles Bibliográficos
Autores principales: Oleksak, Patrik, Psotka, Miroslav, Vancurova, Marketa, Sapega, Olena, Bieblova, Jana, Reinis, Milan, Rysanek, David, Mikyskova, Romana, Chalupova, Katarina, Malinak, David, Svobodova, Jana, Andrys, Rudolf, Rehulkova, Helena, Skopek, Vojtech, Ngoc Lam, Pham, Bartek, Jiri, Hodny, Zdenek, Musilek, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808747/
https://www.ncbi.nlm.nih.gov/pubmed/33440995
http://dx.doi.org/10.1080/14756366.2020.1871336

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