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An information-theoretical analysis of gene nucleotide sequence structuredness for a selection of aging and cancer-related genes

We provide an algorithm for the construction and analysis of autocorrelation (information) functions of gene nucleotide sequences. As a measure of correlation between discrete random variables, we use normalized mutual information. The information functions are indicative of the degree of structured...

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Detalles Bibliográficos
Autores principales: Blokh, David, Gitarts, Joseph, Stambler, Ilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Genome Organization 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808870/
https://www.ncbi.nlm.nih.gov/pubmed/33412757
http://dx.doi.org/10.5808/GI.2020.18.4.e41
Descripción
Sumario:We provide an algorithm for the construction and analysis of autocorrelation (information) functions of gene nucleotide sequences. As a measure of correlation between discrete random variables, we use normalized mutual information. The information functions are indicative of the degree of structuredness of gene sequences. We construct the information functions for selected gene sequences. We find a significant difference between information functions of genes of different types. We hypothesize that the features of information functions of gene nucleotide sequences are related to phenotypes of these genes.