BaSDAS: a web-based pooled CRISPR-Cas9 knockout screening data analysis system

We developed the BaSDAS (Barcode-Seq Data Analysis System), a GUI-based pooled knockout screening data analysis system, to facilitate the analysis of pooled knockout screen data easily and effectively by researchers with limited bioinformatics skills. The BaSDAS supports the analysis of various pool...

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Detalles Bibliográficos
Autores principales: Park, Young-Kyu, Yoon, Byoung-Ha, Park, Seung-Jin, Kim, Byung Kwon, Kim, Seon-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Genome Organization 2020
Materias:
Application Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808871/
https://www.ncbi.nlm.nih.gov/pubmed/33412762
http://dx.doi.org/10.5808/GI.2020.18.4.e46
Descripción
Sumario:We developed the BaSDAS (Barcode-Seq Data Analysis System), a GUI-based pooled knockout screening data analysis system, to facilitate the analysis of pooled knockout screen data easily and effectively by researchers with limited bioinformatics skills. The BaSDAS supports the analysis of various pooled screening libraries, including yeast, human, and mouse libraries, and provides many useful statistical and visualization functions with a user-friendly web interface for convenience. We expect that BaSDAS will be a useful tool for the analysis of genome-wide screening data and will support the development of novel drugs based on functional genomics information.

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