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Counteracting CAR T cell dysfunction

In spite of high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, the efficacy of this approach is limited by generation of dysfunctional CAR T cells in vivo, conceivably induced by immunosuppressive tumor microenvironment (TME) and excessive antigen exposure. Ex...

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Detalles Bibliográficos
Autores principales:	Poorebrahim, Mansour, Melief, Jeroen, Pico de Coaña, Yago, L. Wickström, Stina, Cid-Arregui, Angel, Kiessling, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808935/ https://www.ncbi.nlm.nih.gov/pubmed/33168929 http://dx.doi.org/10.1038/s41388-020-01501-x

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