The p53/p73 - p21(CIP1) tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells

Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus end assembly rates during mitosis leading to the generation of lagging chromosomes during anaphase as a major form of mito...

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Detalles Bibliográficos
Autores principales: Schmidt, Ann-Kathrin, Pudelko, Karoline, Boekenkamp, Jan-Eric, Berger, Katharina, Kschischo, Maik, Bastians, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808936/
https://www.ncbi.nlm.nih.gov/pubmed/33168930
http://dx.doi.org/10.1038/s41388-020-01524-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808936/
https://www.ncbi.nlm.nih.gov/pubmed/33168930
http://dx.doi.org/10.1038/s41388-020-01524-4

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