Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations

Lung adenocarcinoma (LUAD) harboring EGFR mutations prevails in Asian population. However, the inter-patient and intra-tumor heterogeneity has not been addressed at single-cell resolution. Here we performed single-cell RNA sequencing (scRNA-seq) of total 125,674 cells from seven stage-I/II LUAD samp...

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Detalles Bibliográficos
Autores principales: He, Di, Wang, Di, Lu, Ping, Yang, Nan, Xue, Zhigang, Zhu, Xianmin, Zhang, Peng, Fan, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808940/
https://www.ncbi.nlm.nih.gov/pubmed/33144684
http://dx.doi.org/10.1038/s41388-020-01528-0

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