Influence of Cow’s Milk and Esomeprazole on the Absorption of Erlotinib: A Randomized, Crossover Pharmacokinetic Study in Lung Cancer Patients

INTRODUCTION: Erlotinib’s gastrointestinal solubility and absorption are decreased by proton pump inhibitors (PPIs). Since erlotinib is a lipophilic drug, we hypothesized that concomitant intake with the fatty beverage milk may be a feasible way to increase erlotinib uptake. We performed a two-perio...

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Detalles Bibliográficos
Autores principales: Veerman, G. D. Marijn, Hussaarts, Koen G. A. M., Peric, Robert, Oomen-de Hoop, Esther, Landa, Kersten D., van der Leest, Cor H., Broerse, Suzanna D., Rutten, Hugo B., Belderbos, Huub N. A., Steendam, Christi M. J., Paats, Marthe S., Koolen, Stijn L. W., Dingemans, Anne-Marie C., van Gelder, Teun, van Leeuwen, Roelof W. F., Aerts, Joachim G. J. V., Mathijssen, Ron H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808986/
https://www.ncbi.nlm.nih.gov/pubmed/32557346
http://dx.doi.org/10.1007/s40262-020-00910-1

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