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Machine learning predicts lymph node metastasis of poorly differentiated-type intramucosal gastric cancer

To construct a machine learning algorithm model of lymph node metastasis (LNM) in patients with poorly differentiated-type intramucosal gastric cancer. 1169 patients with postoperative gastric cancer were divided into a training group and a test group at a ratio of 7:3. The model for lymph node meta...

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Autores principales: Zhou, Cheng-Mao, Wang, Ying, Ye, Hao-Tian, Yan, Shuping, Ji, Muhuo, Liu, Panmiao, Yang, Jian-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809018/
https://www.ncbi.nlm.nih.gov/pubmed/33446730
http://dx.doi.org/10.1038/s41598-020-80582-w
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author Zhou, Cheng-Mao
Wang, Ying
Ye, Hao-Tian
Yan, Shuping
Ji, Muhuo
Liu, Panmiao
Yang, Jian-Jun
author_facet Zhou, Cheng-Mao
Wang, Ying
Ye, Hao-Tian
Yan, Shuping
Ji, Muhuo
Liu, Panmiao
Yang, Jian-Jun
author_sort Zhou, Cheng-Mao
collection PubMed
description To construct a machine learning algorithm model of lymph node metastasis (LNM) in patients with poorly differentiated-type intramucosal gastric cancer. 1169 patients with postoperative gastric cancer were divided into a training group and a test group at a ratio of 7:3. The model for lymph node metastasis was established with python machine learning. The Gbdt algorithm in the machine learning results finds that number of resected nodes, lymphovascular invasion and tumor size are the primary 3 factors that account for the weight of LNM. Effect of the LNM model of PDC gastric cancer patients in the training group: Among the 7 algorithm models, the highest accuracy rate was that of GBDT (0.955); The AUC values for the 7 algorithms were, from high to low, XGB (0.881), RF (0.802), GBDT (0.798), LR (0.778), XGB + LR (0.739), RF + LR (0.691) and GBDT + LR (0.626). Results of the LNM model of PDC gastric cancer patients in test group : Among the 7 algorithmic models, XGB had the highest accuracy rate (0.952); Among the 7 algorithms, the AUC values, from high to low, were GBDT (0.788), RF (0.765), XGB (0.762), LR (0.750), RF + LR (0.678), GBDT + LR (0.650) and XGB + LR (0.619). Single machine learning algorithm can predict LNM in poorly differentiated-type intramucosal gastric cancer, but fusion algorithm can not improve the effect of machine learning in predicting LNM.
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spelling pubmed-78090182021-01-15 Machine learning predicts lymph node metastasis of poorly differentiated-type intramucosal gastric cancer Zhou, Cheng-Mao Wang, Ying Ye, Hao-Tian Yan, Shuping Ji, Muhuo Liu, Panmiao Yang, Jian-Jun Sci Rep Article To construct a machine learning algorithm model of lymph node metastasis (LNM) in patients with poorly differentiated-type intramucosal gastric cancer. 1169 patients with postoperative gastric cancer were divided into a training group and a test group at a ratio of 7:3. The model for lymph node metastasis was established with python machine learning. The Gbdt algorithm in the machine learning results finds that number of resected nodes, lymphovascular invasion and tumor size are the primary 3 factors that account for the weight of LNM. Effect of the LNM model of PDC gastric cancer patients in the training group: Among the 7 algorithm models, the highest accuracy rate was that of GBDT (0.955); The AUC values for the 7 algorithms were, from high to low, XGB (0.881), RF (0.802), GBDT (0.798), LR (0.778), XGB + LR (0.739), RF + LR (0.691) and GBDT + LR (0.626). Results of the LNM model of PDC gastric cancer patients in test group : Among the 7 algorithmic models, XGB had the highest accuracy rate (0.952); Among the 7 algorithms, the AUC values, from high to low, were GBDT (0.788), RF (0.765), XGB (0.762), LR (0.750), RF + LR (0.678), GBDT + LR (0.650) and XGB + LR (0.619). Single machine learning algorithm can predict LNM in poorly differentiated-type intramucosal gastric cancer, but fusion algorithm can not improve the effect of machine learning in predicting LNM. Nature Publishing Group UK 2021-01-14 /pmc/articles/PMC7809018/ /pubmed/33446730 http://dx.doi.org/10.1038/s41598-020-80582-w Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhou, Cheng-Mao
Wang, Ying
Ye, Hao-Tian
Yan, Shuping
Ji, Muhuo
Liu, Panmiao
Yang, Jian-Jun
Machine learning predicts lymph node metastasis of poorly differentiated-type intramucosal gastric cancer
title Machine learning predicts lymph node metastasis of poorly differentiated-type intramucosal gastric cancer
title_full Machine learning predicts lymph node metastasis of poorly differentiated-type intramucosal gastric cancer
title_fullStr Machine learning predicts lymph node metastasis of poorly differentiated-type intramucosal gastric cancer
title_full_unstemmed Machine learning predicts lymph node metastasis of poorly differentiated-type intramucosal gastric cancer
title_short Machine learning predicts lymph node metastasis of poorly differentiated-type intramucosal gastric cancer
title_sort machine learning predicts lymph node metastasis of poorly differentiated-type intramucosal gastric cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809018/
https://www.ncbi.nlm.nih.gov/pubmed/33446730
http://dx.doi.org/10.1038/s41598-020-80582-w
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