Cargando…

A disease-relevant mutation of SPOP highlights functional significance of ATM-mediated DNA damage response

Detalles Bibliográficos
Autores principales:	Xiao, Mingming, Fried, Joshua S., Ma, Jinlu, Su, Yang, Boohaker, Rebecca J., Zeng, Qinghua, Mo, Yaqi, Meng, Fanbiao, Xiang, Rong, Xu, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809020/ https://www.ncbi.nlm.nih.gov/pubmed/33446628 http://dx.doi.org/10.1038/s41392-020-00381-7

Ejemplares similares

The SPOP-ITCH Signaling Axis Protects Against Prostate Cancer Metastasis
por: Ma, Jinlu, et al.
Publicado: (2021)

Dual-functional significance of ATM-mediated phosphorylation of spindle assembly checkpoint component Bub3 in mitosis and the DNA damage response
por: Xiao, Mingming, et al.
Publicado: (2022)

ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication
por: Wang, Dejie, et al.
Publicado: (2021)

Functional roles of Speckle-Type Poz (SPOP) Protein in Genomic stability
por: Wei, Xi, et al.
Publicado: (2018)

The Roles of SPOP in DNA Damage Response and DNA Replication
por: Maekawa, Masashi, et al.
Publicado: (2020)

SPOP the mutation
por: Rider, Leah, et al.
Publicado: (2015)

The establishment of an immunosensor for the detection of SPOP
por: Yue, Song, et al.
Publicado: (2021)

ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors
por: Ueno, Sayaka, et al.
Publicado: (2022)

SPOP loss of function protects against tauopathy
por: Eck, Randall J., et al.
Publicado: (2022)

SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway
por: Luo, Zhenzhen, et al.
Publicado: (2021)

DNA mismatch repair protein Mlh1 is required for tetravalent chromium intermediate-induced DNA damage
por: Wakeman, Timothy P., et al.
Publicado: (2017)

Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP–HIPK2 axis
por: Jin, Xiaofeng, et al.
Publicado: (2021)

Relevance of ATM Status in Driving Sensitivity to DNA Damage Response Inhibitors in Patient-Derived Xenograft Models
por: Karmokar, Ankur, et al.
Publicado: (2023)

SPOP Deregulation Improves the Radiation Response of Prostate Cancer Models by Impairing DNA Damage Repair
por: El Bezawy, Rihan, et al.
Publicado: (2020)

SPOP mutation leads to genomic instability in prostate cancer
por: Boysen, Gunther, et al.
Publicado: (2015)

Identification of SPOP related metabolic pathways in prostate cancer
por: Yan, Min, et al.
Publicado: (2017)

The emerging role of SPOP protein in tumorigenesis and cancer therapy
por: Song, Yizuo, et al.
Publicado: (2020)

SPOP Inhibition of Endometrial Carcinoma and Its Clinicopathological Relationship
por: Zhu, Qing, et al.
Publicado: (2022)

SPOP regulates the expression profiles and alternative splicing events in human hepatocytes
por: Dai, Jing, et al.
Publicado: (2023)

SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG
por: Tan, Peng, et al.
Publicado: (2019)

Association of SPOP Expression with the Immune Response to Salmonella Infection in Chickens
por: Wang, Fei, et al.
Publicado: (2020)

SPOP in Cancer: Phenomena, Mechanisms and Its Role in Therapeutic Implications
por: Yang, Xiaojuan, et al.
Publicado: (2022)

Retracted: SPOP Inhibition of Endometrial Carcinoma and Its Clinicopathological Relationship
por: and Biomechanics, Applied Bionics
Publicado: (2023)

SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability
por: Ju, Lin-Gao, et al.
Publicado: (2018)

SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer
por: Zeng, Chunyan, et al.
Publicado: (2014)

The ATM Gene in Breast Cancer: Its Relevance in Clinical Practice
por: Stucci, Luigia Stefania, et al.
Publicado: (2021)

Prognostic Significance of Nuclear Phospho-ATM Expression in Melanoma
por: Bhandaru, Madhuri, et al.
Publicado: (2015)

Impact of the SPOP Mutant Subtype on the Interpretation of Clinical Parameters in Prostate Cancer
por: Liu, Deli, et al.
Publicado: (2018)

Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles
por: Marzahn, Melissa R, et al.
Publicado: (2016)

G3BP1 modulates SPOP to promote prostate tumorigenesis
por: Mukhopadhyay, Chandrani, et al.
Publicado: (2022)

Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity
por: Usher, Emery T., et al.
Publicado: (2021)

Key pathways in prostate cancer with SPOP mutation identified by bioinformatic analysis
por: Ding, Guanxiong, et al.
Publicado: (2020)

Cul3 substrate adaptor SPOP targets Nup153 for degradation
por: Ong, Joseph Y., et al.
Publicado: (2023)

SPOP targets the immune transcription factor IRF1 for proteasomal degradation
por: Schwartz, Irene, et al.
Publicado: (2023)

The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response
por: Karlseder, Jan, et al.
Publicado: (2004)

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
por: Qian, Minxian, et al.
Publicado: (2018)

Role of the ATM gene in radiation sensitivity, relevance to breast cancer treatment
por: Hall, J, et al.
Publicado: (2000)

SPOP is essential for DNA–protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex
por: Watanabe, Ryuta, et al.
Publicado: (2020)

Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition
por: Aguilar-Quesada, Rocío, et al.
Publicado: (2007)

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
por: So, Sairei, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_mea756so7r0r7m9ua0394cp2vc