An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy

During autophagy the enzyme Atg3 catalyzes the covalent conjugation of LC3 to the amino group of phosphatidylethanolamine (PE) lipids, which is one of the key steps in autophagosome formation. Here, we have demonstrated that an N-terminal conserved region of human Atg3 (hAtg3) communicates informati...

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Detalles Bibliográficos
Autores principales: Ye, Yansheng, Tyndall, Erin R., Bui, Van, Tang, Zhenyuan, Shen, Yan, Jiang, Xuejun, Flanagan, John M., Wang, Hong-Gang, Tian, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809043/
https://www.ncbi.nlm.nih.gov/pubmed/33446636
http://dx.doi.org/10.1038/s41467-020-20607-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809043/
https://www.ncbi.nlm.nih.gov/pubmed/33446636
http://dx.doi.org/10.1038/s41467-020-20607-0

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