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The effects of meldonium on the acute ischemia/reperfusion liver injury in rats
Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/k...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809046/ https://www.ncbi.nlm.nih.gov/pubmed/33446709 http://dx.doi.org/10.1038/s41598-020-80011-y |
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author | Đurašević, Siniša Stojković, Maja Sopta, Jelena Pavlović, Slađan Borković-Mitić, Slavica Ivanović, Anđelija Jasnić, Nebojša Tosti, Tomislav Đurović, Saša Đorđević, Jelena Todorović, Zoran |
author_facet | Đurašević, Siniša Stojković, Maja Sopta, Jelena Pavlović, Slađan Borković-Mitić, Slavica Ivanović, Anđelija Jasnić, Nebojša Tosti, Tomislav Đurović, Saša Đorđević, Jelena Todorović, Zoran |
author_sort | Đurašević, Siniša |
collection | PubMed |
description | Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures. |
format | Online Article Text |
id | pubmed-7809046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78090462021-01-15 The effects of meldonium on the acute ischemia/reperfusion liver injury in rats Đurašević, Siniša Stojković, Maja Sopta, Jelena Pavlović, Slađan Borković-Mitić, Slavica Ivanović, Anđelija Jasnić, Nebojša Tosti, Tomislav Đurović, Saša Đorđević, Jelena Todorović, Zoran Sci Rep Article Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures. Nature Publishing Group UK 2021-01-14 /pmc/articles/PMC7809046/ /pubmed/33446709 http://dx.doi.org/10.1038/s41598-020-80011-y Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Đurašević, Siniša Stojković, Maja Sopta, Jelena Pavlović, Slađan Borković-Mitić, Slavica Ivanović, Anđelija Jasnić, Nebojša Tosti, Tomislav Đurović, Saša Đorđević, Jelena Todorović, Zoran The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
title | The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
title_full | The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
title_fullStr | The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
title_full_unstemmed | The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
title_short | The effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
title_sort | effects of meldonium on the acute ischemia/reperfusion liver injury in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809046/ https://www.ncbi.nlm.nih.gov/pubmed/33446709 http://dx.doi.org/10.1038/s41598-020-80011-y |
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