Cargando…

Dulaglutide exerts beneficial anti atherosclerotic effects in ApoE knockout mice with diabetes: the earlier, the better

There has been no report about the mechanism for anti-atherosclerotic effects of dulaglutide (Dula) and/or about the difference of its effectiveness between in an early and a late phase of diabetes. To address such questions, streptozotocin (STZ) was intraperitoneally injected to ApoE knockout mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sanada, Junpei, Obata, Atsushi, Obata, Yoshiyuki, Fushimi, Yoshiro, Shimoda, Masashi, Kohara, Kenji, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809053/ https://www.ncbi.nlm.nih.gov/pubmed/33446799 http://dx.doi.org/10.1038/s41598-020-80894-x

Ejemplares similares

Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: “The Earlier, the Better” in Therapy with Incretin-Based Medicine
por: Kaneto, Hideaki, et al.
Publicado: (2021)

Early combination therapy of empagliflozin and linagliptin exerts beneficial effects on pancreatic β cells in diabetic db/db mice
por: Fushimi, Yoshiro, et al.
Publicado: (2021)

Association between Grit Scales and adherence to regular hospital visits among Japanese patients with type 2 diabetes: Prospective observational study
por: Nakanishi, Shuhei, et al.
Publicado: (2021)

Idiopathic Bilateral Extraocular Myositis in a Subject With Poorly Controlled Type 2 Diabetes Mellitus: Case Report
por: Tatsumi, Fuminori, et al.
Publicado: (2021)

Switching From Daily DPP-4 Inhibitor to Once-Weekly GLP-1 Receptor Activator Dulaglutide Significantly Ameliorates Glycemic Control in Subjects With Poorly Controlled Type 2 Diabetes Mellitus: A Retrospective Observational Study
por: Sanada, Junpei, et al.
Publicado: (2021)

Clinical Characteristics of Withdrawal of Basal Insulin Therapy Among Japanese Patients with Type 2 Diabetes: A Multicenter Retrospective Observational Study
por: Nakanishi, Shuhei, et al.
Publicado: (2021)

Multiple endocrine neoplasia type 1 with a frameshift mutation in its gene accompanied by a giant cervical lipoma and multiple fatty deposits in the pancreas: case report
por: Fushimi, Yoshiro, et al.
Publicado: (2021)

Association Between Severity of Diabetic Neuropathy and Success in Weight Loss During Hospitalization Among Japanese Patients with Type 2 Diabetes: A Retrospective Observational Study
por: Nakanishi, Shuhei, et al.
Publicado: (2020)

Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules
por: Sanada, Junpei, et al.
Publicado: (2022)

Case Report: A Case of Pituitary Adenoma Producing Growth Hormone and Thyroid-Stimulating Hormone Simultaneously
por: Sanada, Junpei, et al.
Publicado: (2021)

Amelioration of hypercalcemia by cinacalcet treatment in a subject with relapsing acquired hypocalciuric hypercalcemia: A case report
por: Sanada, Junpei, et al.
Publicado: (2021)

Concurrence of overt Cushing’s syndrome and primary aldosteronism accompanied by aldosterone-producing cell cluster in adjacent adrenal cortex: case report
por: Fushimi, Yoshiro, et al.
Publicado: (2021)

Switching from low‐dose thiazide diuretics to sodium–glucose cotransporter 2 inhibitor improves various metabolic parameters without affecting blood pressure in patients with type 2 diabetes and hypertension
por: Kimura, Tomohiko, et al.
Publicado: (2017)

There is a Close Association Between the Recovery of Liver Injury and Glycemic Control after SGLT2 Inhibitor Treatment in Japanese Subjects with Type 2 Diabetes: A Retrospective Clinical Study
por: Kinoshita, Tomoe, et al.
Publicado: (2018)

Verification of Kumamoto Declaration 2013 and Glycemic Targets for Elderly Patients with Diabetes in Japan for prevention of diabetic complications: A retrospective longitudinal study using outpatient clinical data
por: Nakanishi, Shuhei, et al.
Publicado: (2018)

Case Report: A Variety of Immune-Related Adverse Events Triggered by Immune Checkpoint Inhibitors in a Subject With Malignant Melanoma: Destructive Thyroiditis, Aseptic Meningitis and Isolated ACTH Deficiency
por: Katakura, Yukino, et al.
Publicado: (2021)

Effect of mild exercise on glycemic and bodyweight control in Japanese type 2 diabetes patients: A retrospective analysis
por: Nakanishi, Shuhei, et al.
Publicado: (2018)

Werner Syndrome and Diabetes Mellitus Accompanied by Adrenal Cortex Cancer
por: Nishioka, Momoyo, et al.
Publicado: (2017)

Effects of sedentary behavior and daily walking steps on body mass index and body composition: Prospective observational study using outpatient clinical data of Japanese patients with type 2 diabetes
por: Nakanishi, Shuhei, et al.
Publicado: (2021)

Idiopathic and isolated adrenocorticotropic hormone deficiency presenting as continuous epigastric discomfort without symptoms of hypoglycemia: a case report
por: Okauchi, Seizo, et al.
Publicado: (2019)

Incidence of endocrine-related immune-related adverse events in Japanese subjects with various types of cancer
por: Iwamoto, Yuichiro, et al.
Publicado: (2023)

Influence of Nutritional Guidance/Consulting on Glycemic Control during the Coronavirus Disease 2019 Pandemic in Patients with Type 2 Diabetes Mellitus
por: Iwamoto, Yuichiro, et al.
Publicado: (2023)

Efficacy and Safety of Switching from Insulin Glargine 100 U/mL to the Same Dose of Glargine 300 U/mL in Japanese Type 1 and 2 Diabetes Patients: A Retrospective Analysis
por: Nakanishi, Shuhei, et al.
Publicado: (2018)

Eicosapentaenoic acid/arachidonic acid ratio and weight loss during hospitalization for glycemic control among overweight Japanese patients with type 2 diabetes: a retrospective observational study
por: Nakanishi, Shuhei, et al.
Publicado: (2019)

Comparison of the effects of three kinds of glucose‐lowering drugs on non‐alcoholic fatty liver disease in patients with type 2 diabetes: A randomized, open‐label, three‐arm, active control study
por: Kinoshita, Tomoe, et al.
Publicado: (2020)

Comprehensive Search for GPCR Compounds which Can Enhance MafA and/or PDX-1 Expression Levels Using a Small Molecule Compound Library
por: Kaneto, Hideaki, et al.
Publicado: (2023)

Effect of Combination Therapy of Canagliflozin Added to Teneligliptin Monotherapy in Japanese Subjects with Type 2 Diabetes Mellitus: A Retrospective Study
por: Fushimi, Yoshiro, et al.
Publicado: (2020)

Impact of physical activity and sedentary time on glycated hemoglobin levels and body composition: Cross‐sectional study using outpatient clinical data of Japanese patients with type 2 diabetes
por: Nakanishi, Shuhei, et al.
Publicado: (2019)

Administration of RAS Inhibitor before the Onset of Diabetic Nephropathy Counteracts the Adverse Effect of Chronic Hyperglycemia and Reduces the Augmentation of Urinary Albumin Excretion: A Retrospective Clinical Study
por: Hirukawa, Hidenori, et al.
Publicado: (2018)

Persistent Hypoglycemia Induced by Long-acting Insulin Degludec
por: Katakura, Yukino, et al.
Publicado: (2021)

Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice
por: Obata, Atsushi, et al.
Publicado: (2019)

A Male Subject with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency Which Was Diagnosed at 31 Years Old due to Infertility
por: Kaneto, Hideaki, et al.
Publicado: (2023)

A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time
por: Isobe, Hayato, et al.
Publicado: (2021)

Case report of severe hypoglycemic alcoholic ketoacidosis: A possible pitfall in diagnosis of ketoacidosis
por: Okauchi, Seizo, et al.
Publicado: (2022)

Immune checkpoint inhibitor-induced hypothyroidism predicts treatment response in Japanese subjects
por: Iwamoto, Yuichiro, et al.
Publicado: (2023)

Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus
por: Kaneto, Hideaki, et al.
Publicado: (2022)

Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects
por: Hirata, Yurie, et al.
Publicado: (2017)

Dramatic recovery without steroid therapy and withdrawal from insulin therapy in a subject with hyperglycemic and hyperosmolar syndrome and depletion of insulin secretory capacity induced by type 2 autoimmune pancreatitis: A case report
por: Iwamoto, Yuichiro, et al.
Publicado: (2022)

Syndrome of inappropriate secretion of thyroid-stimulating hormone in a subject with galactorrhea and menstrual disorder and undergoing infertility treatment: Case report
por: Kaneto, Hideaki, et al.
Publicado: (2021)

Notable Underlying Mechanism for Pancreatic β-Cell Dysfunction and Atherosclerosis: Pleiotropic Roles of Incretin and Insulin Signaling
por: Kaneto, Hideaki, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cihg3v500punv5sbmi6nljkfg5