Cargando…

The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells

Dendritic cells (DCs) promote T-cell mediated tolerance to self-antigens and induce inflammation to innocuous-antigens. This dual potential makes DCs fundamental players in inflammatory disorders. Evidence from inflammatory colitis mouse models and inflammatory bowel diseases (IBD) patients indicate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Doñas, Cristian, Neira, Jocelyn, Osorio-Barrios, Francisco, Carrasco, Macarena, Fernández, Dominique, Prado, Carolina, Loyola, Alejandra, Pacheco, Rodrigo, Rosemblatt, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809056/ https://www.ncbi.nlm.nih.gov/pubmed/33446666 http://dx.doi.org/10.1038/s41598-020-79122-3

Ejemplares similares

Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells
por: Doñas, Cristian, et al.
Publicado: (2013)

The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells
por: Sui, Aixia, et al.
Publicado: (2017)

Retinoic Acid as a Modulator of T Cell Immunity
por: Bono, Maria Rosa, et al.
Publicado: (2016)

The JMJD3 histone demethylase inhibitor GSK-J1 ameliorates lipopolysaccharide-induced inflammation in a mastitis model
por: Wang, Jing-Jing, et al.
Publicado: (2022)

Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia
por: Li, Yunan, et al.
Publicado: (2018)

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
por: Kawamura, Akane, et al.
Publicado: (2017)

Structural Plasticity of Dendritic Spines Requires GSK3α and GSK3β
por: Cymerman, Iwona A., et al.
Publicado: (2015)

The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays
por: Lobo-Silva, Jessica, et al.
Publicado: (2020)

The Histone Demethylase Inhibitor GSK-J4 Is a Therapeutic Target for the Kidney Fibrosis of Diabetic Kidney Disease via DKK1 Modulation
por: Hung, Peir-Haur, et al.
Publicado: (2022)

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
por: Sun, Cheng-Ming, et al.
Publicado: (2007)

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
por: Benson, Micah J., et al.
Publicado: (2007)

Purinergic Signaling as a Regulator of Th17 Cell Plasticity
por: Fernández, Dominique, et al.
Publicado: (2016)

Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer
por: Morozov, Viacheslav M., et al.
Publicado: (2017)

Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
por: Viscarra, Jose A., et al.
Publicado: (2020)

Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells
por: Candia, Enzo, et al.
Publicado: (2017)

Dopamine Receptor D5 Signaling Plays a Dual Role in Experimental Autoimmune Encephalomyelitis Potentiating Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T-Cells
por: Osorio-Barrios, Francisco, et al.
Publicado: (2018)

Effect of Size and Loading of Retinoic Acid in Polyvinyl Butyrate Nanoparticles on Amelioration of Colitis
por: Li, Jinting, et al.
Publicado: (2021)

GSK-J4 Inhibition of KDM6B Histone Demethylase Blocks Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells by Modulating NF-κB Signaling
por: Sadeghi, Laia, et al.
Publicado: (2023)

Adoptive transfer of autoimmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral response
por: Sauma, Daniela, et al.
Publicado: (2017)

Generation and transcriptional programming of intestinal dendritic cells: Essential role of retinoic acid
por: Zeng, Ruizhu, et al.
Publicado: (2015)

Retinoic Acid Signaling Is Required for Dendritic Cell Maturation and the Induction of T Cell Immunity
por: Farazuddin, Mohammad, et al.
Publicado: (2023)

GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis
por: Xu, Kai, et al.
Publicado: (2022)

Histone demethylase lysine demethylase 5B in development and cancer
por: Han, Mengjiao, et al.
Publicado: (2016)

GSK-3β and MMP-9 Cooperate in the Control of Dendritic Spine Morphology
por: Kondratiuk, Ilona, et al.
Publicado: (2016)

Retinoic acid regulates the development of a gut homing precursor for intestinal dendritic cells
por: Zeng, Ruizhu, et al.
Publicado: (2012)

Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid
por: Jones, Lucy H., et al.
Publicado: (2015)

Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity
por: Thapliyal, Shruti, et al.
Publicado: (2022)

GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation
por: Morgan-Smith, Meghan, et al.
Publicado: (2014)

Prostaglandin E2 suppresses the differentiation of retinoic acid–producing dendritic cells in mice and humans
por: Stock, Angus, et al.
Publicado: (2011)

Retinoic acid controls the homeostasis of pre-cDC–derived splenic and intestinal dendritic cells
por: Klebanoff, Christopher A., et al.
Publicado: (2013)

Correction: Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity
por: Thapliyal, Shruti, et al.
Publicado: (2023)

Investigation of distribution of GSK-3β signal pathway by age groups in cases of ulcerative colitis
por: Ozbey, Caner, et al.
Publicado: (2023)

An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae/butyrate/retinoic acid axis
por: Wang, Lifu, et al.
Publicado: (2021)

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes
por: Smitheman, Kimberly N., et al.
Publicado: (2019)

Severe de novo Ulcerative Colitis following Ixekizumab Therapy
por: Philipose, Jobin, et al.
Publicado: (2018)

An improved de novo assembling and polishing of Solea senegalensis transcriptome shed light on retinoic acid signalling in larvae
por: Córdoba-Caballero, José, et al.
Publicado: (2020)

GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity
por: Yokota, Aya, et al.
Publicado: (2009)

The retinoic acid-producing capacity of gut dendritic cells and macrophages is reduced during persistent T. muris infection
por: Hurst, R J M, et al.
Publicado: (2013)

Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells
por: VanGundy, Zachary C, et al.
Publicado: (2014)

Human Gastric Epithelial Cells Contribute to Gastric Immune Regulation by Providing Retinoic Acid to Dendritic Cells
por: Bimczok, Diane, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_2smebkaje4f36nqq7nng3b4la4