Increased and More Heterogeneous Gadoxetic Acid Uptake of the Liver Parenchyma after Hepatitis C Virus Eradication by Direct Antiviral Agent

We evaluated the changes of gadoxetic acid uptake of the liver parenchyma after hepatitis C virus (HCV) eradication by direct-antiviral agent (DAA) therapy. The increase rate of the liver-to-muscle signal intensity ratio, the skewness and the kurtosis were calculated in the hepatobiliary phase. Afte...

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Autores principales: Fujita, Nobuhiro, Nishie, Akihiro, Asayama, Yoshiki, Ishigami, Kousei, Nakayama, Tomohiro, Ushijima, Yasuhiro, Kakihara, Daisuke, Takayama, Yukihisa, Morita, Koichiro, Ishimatsu, Keisuke, Takao, Seiichiro, Yoshizumi, Tomoharu, Furusyo, Norihiro, Honda, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Magnetic Resonance in Medicine 2020
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809143/
https://www.ncbi.nlm.nih.gov/pubmed/32051362
http://dx.doi.org/10.2463/mrms.tn.2019-0183
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author Fujita, Nobuhiro
Nishie, Akihiro
Asayama, Yoshiki
Ishigami, Kousei
Nakayama, Tomohiro
Ushijima, Yasuhiro
Kakihara, Daisuke
Takayama, Yukihisa
Morita, Koichiro
Ishimatsu, Keisuke
Takao, Seiichiro
Yoshizumi, Tomoharu
Furusyo, Norihiro
Honda, Hiroshi
author_facet Fujita, Nobuhiro
Nishie, Akihiro
Asayama, Yoshiki
Ishigami, Kousei
Nakayama, Tomohiro
Ushijima, Yasuhiro
Kakihara, Daisuke
Takayama, Yukihisa
Morita, Koichiro
Ishimatsu, Keisuke
Takao, Seiichiro
Yoshizumi, Tomoharu
Furusyo, Norihiro
Honda, Hiroshi
author_sort Fujita, Nobuhiro
collection PubMed
description We evaluated the changes of gadoxetic acid uptake of the liver parenchyma after hepatitis C virus (HCV) eradication by direct-antiviral agent (DAA) therapy. The increase rate of the liver-to-muscle signal intensity ratio, the skewness and the kurtosis were calculated in the hepatobiliary phase. After sustained virological response, gadoxetic acid uptake of the liver parenchyma increased, but became heterogeneous. Our study proved that HCV eradication by DAA therapy could significantly affect gadoxetic acid uptake.
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spelling pubmed-78091432021-01-27 Increased and More Heterogeneous Gadoxetic Acid Uptake of the Liver Parenchyma after Hepatitis C Virus Eradication by Direct Antiviral Agent Fujita, Nobuhiro Nishie, Akihiro Asayama, Yoshiki Ishigami, Kousei Nakayama, Tomohiro Ushijima, Yasuhiro Kakihara, Daisuke Takayama, Yukihisa Morita, Koichiro Ishimatsu, Keisuke Takao, Seiichiro Yoshizumi, Tomoharu Furusyo, Norihiro Honda, Hiroshi Magn Reson Med Sci Technical Note We evaluated the changes of gadoxetic acid uptake of the liver parenchyma after hepatitis C virus (HCV) eradication by direct-antiviral agent (DAA) therapy. The increase rate of the liver-to-muscle signal intensity ratio, the skewness and the kurtosis were calculated in the hepatobiliary phase. After sustained virological response, gadoxetic acid uptake of the liver parenchyma increased, but became heterogeneous. Our study proved that HCV eradication by DAA therapy could significantly affect gadoxetic acid uptake. Japanese Society for Magnetic Resonance in Medicine 2020-02-13 /pmc/articles/PMC7809143/ /pubmed/32051362 http://dx.doi.org/10.2463/mrms.tn.2019-0183 Text en © 2020 Japanese Society for Magnetic Resonance in Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Technical Note
Fujita, Nobuhiro
Nishie, Akihiro
Asayama, Yoshiki
Ishigami, Kousei
Nakayama, Tomohiro
Ushijima, Yasuhiro
Kakihara, Daisuke
Takayama, Yukihisa
Morita, Koichiro
Ishimatsu, Keisuke
Takao, Seiichiro
Yoshizumi, Tomoharu
Furusyo, Norihiro
Honda, Hiroshi
Increased and More Heterogeneous Gadoxetic Acid Uptake of the Liver Parenchyma after Hepatitis C Virus Eradication by Direct Antiviral Agent
title Increased and More Heterogeneous Gadoxetic Acid Uptake of the Liver Parenchyma after Hepatitis C Virus Eradication by Direct Antiviral Agent
title_full Increased and More Heterogeneous Gadoxetic Acid Uptake of the Liver Parenchyma after Hepatitis C Virus Eradication by Direct Antiviral Agent
title_fullStr Increased and More Heterogeneous Gadoxetic Acid Uptake of the Liver Parenchyma after Hepatitis C Virus Eradication by Direct Antiviral Agent
title_full_unstemmed Increased and More Heterogeneous Gadoxetic Acid Uptake of the Liver Parenchyma after Hepatitis C Virus Eradication by Direct Antiviral Agent
title_short Increased and More Heterogeneous Gadoxetic Acid Uptake of the Liver Parenchyma after Hepatitis C Virus Eradication by Direct Antiviral Agent
title_sort increased and more heterogeneous gadoxetic acid uptake of the liver parenchyma after hepatitis c virus eradication by direct antiviral agent
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809143/
https://www.ncbi.nlm.nih.gov/pubmed/32051362
http://dx.doi.org/10.2463/mrms.tn.2019-0183
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