NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation

Nuclear factor (erythroid-derived 2) like 2 (NRF2) is a nuclear transcription factor activated in response to oxidative stress that induces a gene program that dampens inflammation and can limit cell damage that perpetuates the inflammatory response. We have identified A-1396076, a potent and select...

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Detalles Bibliográficos
Autores principales: Goess, Christian, Terrillon, Sonia, Mayo, Martha, Bousquet, Peter, Wallace, Craig, Hart, Michelle, Mathieu, Suzanne, Twomey, Rachel, Donnelly-Roberts, Diana, Namovic, Marian, Jung, Paul, Hu, Min, Richardson, Paul, Esbenshade, Tim, Cuff, Carolyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809192/
https://www.ncbi.nlm.nih.gov/pubmed/33490940
http://dx.doi.org/10.1016/j.jtauto.2020.100079

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